RESUMO
Nine isoflavonoids including a new pterocarpene, puemiricarpene, were isolated from the tuberous root of Pueraria mirifica (Leguminosae). The structure of puemiricarpene was determined by spectroscopic means. Estrogenic activity of the isolated isoflavonoids was tested using MCF-7 human breast cancer cells. Moderate activity was observed for kwakhurin, a prenylated isoflavonoid.
Assuntos
Estrogênios não Esteroides/química , Estrogênios não Esteroides/farmacologia , Fabaceae/química , Flavonoides/química , Flavonoides/farmacologia , Plantas Medicinais , Humanos , Isoflavonas , Células Tumorais CultivadasRESUMO
Miroestrol (1) has been isolated previously as an active principle from "Kwao Keur" (Pueraria mirifica), a rejuvenating folk medicine from Thailand. Reinvestigation using bioassay-guided purification has resulted in the isolation of a new potent phytoestrogen, deoxymiroestrol (2). The facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.
Assuntos
Antineoplásicos Fitogênicos/análise , Estrogênios não Esteroides/análise , Plantas Medicinais/química , Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Cumarínicos , Ensaios de Seleção de Medicamentos Antitumorais , Estrogênios não Esteroides/isolamento & purificação , Estrogênios não Esteroides/farmacologia , Humanos , Espectrometria de Massas de Bombardeamento Rápido de Átomos , Esteroides , Tailândia , Células Tumorais CultivadasRESUMO
Antiviral activity-guided isolation studies on the leaves of Atalantia monophylla (ROXB.) CORR. (Rutaceae) led to the identification of pyropheophorbide a (1), a simple chlorin derivative, from the chloroform extract (fr. B) as a possible antiviral active principle against herpes simplex virus type 2 (HSV-2). Pyropheophorbide a methyl ester (2) was also isolated from the hexane extract (fr. A).
