RESUMO
The ethanolic extract of Kaempferia parviflora (KP) rhizomes dose-dependently relaxed both aortic rings and ileum precontracted with phenylephrine and acethylcholine, respectively.
Assuntos
Relaxamento Muscular/efeitos dos fármacos , Músculo Liso Vascular/efeitos dos fármacos , Fitoterapia , Extratos Vegetais/farmacologia , Vasodilatadores/farmacologia , Zingiberaceae , Acetilcolina , Animais , Aorta/efeitos dos fármacos , Aorta/fisiopatologia , Relação Dose-Resposta a Droga , Humanos , Íleo/efeitos dos fármacos , Íleo/fisiopatologia , Masculino , Músculo Liso Vascular/fisiopatologia , Fenilefrina , Extratos Vegetais/administração & dosagem , Extratos Vegetais/uso terapêutico , Ratos , Ratos Wistar , Rizoma , Vasodilatadores/administração & dosagem , Vasodilatadores/uso terapêuticoRESUMO
The rhizomes of Kaempferia parviflora (KP) (Zingiberaceae) have been used in Thai traditional medicine for health promotion and for the treatment of digestive disorders and gastric ulcer. This study investigated effect of KP on endothelial function. Studies in human umbilical vein endothelial cells (HUVEC) showed that KP dose-dependently increased nitrite concentrations in culture media after 48 h incubation. eNOS mRNA and protein expression were also enhanced. The induction of eNOS mRNA was detected at 4 h and plateau at 48 h while iNOS expression was not observed. These data demonstrate that KP has a great potential for a supplemental use in vascular endothelial health promotion.
