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Elife ; 122024 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-38805376

RESUMO

Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emerging evidence suggests LD are present in the testis and that loss of neutral lipid- and LD-associated genes causes subfertility; however, key regulators of testis neutral lipids and LD remain unclear. Here, we show LD are present in early-stage somatic and germline cells within the Drosophila testis. We identified a role for triglyceride lipase brummer (bmm) in regulating testis LD, and found that whole-body loss of bmm leads to defects in sperm development. Importantly, these represent cell-autonomous roles for bmm in regulating testis LD and spermatogenesis. Because lipidomic analysis of bmm mutants revealed excess triglyceride accumulation, and spermatogenic defects in bmm mutants were rescued by genetically blocking triglyceride synthesis, our data suggest that bmm-mediated regulation of triglyceride influences sperm development. This identifies triglyceride as an important neutral lipid that contributes to Drosophila sperm development, and reveals a key role for bmm in regulating testis triglyceride levels during spermatogenesis.


Assuntos
Proteínas de Drosophila , Drosophila melanogaster , Lipase , Espermatogênese , Testículo , Triglicerídeos , Animais , Masculino , Triglicerídeos/metabolismo , Proteínas de Drosophila/metabolismo , Proteínas de Drosophila/genética , Testículo/metabolismo , Drosophila melanogaster/metabolismo , Drosophila melanogaster/genética , Lipase/metabolismo , Lipase/genética , Gotículas Lipídicas/metabolismo , Espermatozoides/metabolismo
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