[Clinical value of the study of hemostasis in nephrology]. / Klinicheskoe znachenie issledovaniia gemostaza v nefrologii.

The results of many-year studies on the humoral and platelet links of hemostasis in chronic glomerulonephritis (CGN) and amyloidosis were analyzed with relation to a stage of disease and prognosis of its course. Activation of the blood coagulation system (BCS), platelet hyperaggregation and suppression of the fibrinolytic system were revealed in CGN. Hypercoagulation was most noticeable in patients with active and prognostically unfavorable GGN types correlating with the frequency of local (in the kidney) intravascular coagulation, the frequency of peripheral thromboses and DIC-syndrome. In amyloidosis hypercoagulation shifts of BCS were combined with the activation of fibrinolysis and thrombocytopenia. Pathogenetic, adaptive and compensatory significance of changes of system of hemostasis revealed in CGN and amyloidosis was discussed.

[Characteristics of the aggregative function of thrombocytes in amyloidosis]. / Kharakteristika agregatsionnoi funktsii trombotsitov pri amiloidoze.

In continuity of prior investigations a study was made of platelet aggregation activity stimulated by arachidonic acid in patients with amyloidosis as compared to patients with chronic glomerulonephritis (CGN). Altogether 31 patients with amyloidosis (primary--2, secondary--15, hereditary in periodical disease--14) and 25 CGN patients (latent disease--10, nephrotic--15) were investigated. Considerable changes in platelet aggregation properties in amyloidosis were shown: the absence of aggregation in most of the patients (22) irrespective of a stage of disease and a tendency to prolongation of a latent period in patients in whom it was observed (9). These data were obtained for the first time. Either normal (in patients with latent type) or raised (in patients with nephrotic type) aggregation to a given stimulus was observed in CGN which was well in accord with the results obtained by other authors.