RESUMO
The interactions between nine drugs (baclofen, bupivacaine, chlorpheniramine, ketoconazole, paliperidone, promethazine, propranolol, risperidone and verapamil) and six cyclodextrins (α-CD, ß-CD, γ-CD, HP-ß-CD, HP-γ-CD and Me-ß-CD) or six polymers of cyclodextrins (polyα-CD, polyß-CD, polyγ-CD, polyHP-ß-CD, polyHP-γ-CD and polyMe-ß-CD) were studied by affinity capillary electrophoresis and/or (1)H NMR at pH 2.5. An exhaustive qualitative study was performed through the determination of the retardation factor. Then, four compounds and both ß-CD and polyß-CD were selected for the quantitative study of the interactions at pH 2.5 and 7.0. By comparing the results obtained with the ß-CD and polyß-CD, it appears that the apparent binding constants are up to five times higher with the polymer. The 2D-NMR results seem to indicate that the structure of the polymeric network favours the inclusion of the guest in the hydrophobic cavity of the CD units. Moreover, the poly-CDs have shown very high enantioselective abilities at both pH.
