1.
J Med Chem
; 47(7): 1602-4, 2004 Mar 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15027849
RESUMO
The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of peptidic MC4R antagonists (usually by intracerebro ventricular injection) has been shown in the literature to increase body weight and/or food intake in several rodent models. We report here the identification of a novel nonpeptidic MC4R antagonist and its effects on tumor-induced weight loss in mice following peripheral administration.