[Conservative treatment of breast cancer]. / Konservatnoe lechenie raka molochnoi zhelezy.

The paper is concerned with clinical characterization of 81 breast cancer patients after conservative radio- and hormonotherapy. Of the total number of patients 47 suffered from inoperable tumors as a result of local spreading, 30 patients had serious contraindications for the operation, and 4 patients refused surgical intervention. Of the total number of patients 85% were aged over 50, 69%--over 60.41%--over 70, and 4 patients--over 80. The results of radiotherapy after a radical program and administration of antiestrogens (tamoxifen, zitosonium) were evaluated in 71 patients: in 42 tumors were undetectable, in 16 they were reduced by more than 50% of their primary size. An analysis of short-term results during 1-year follow-up showed that of 50 patients complete remission was observed in 24, stabilization of a tumor process was achieved in 8. The results should be regarded as promising with relation to the patients' age, status, tumor spreading, and concomitant diseases.

[An experience with the conservative treatment of breast cancer in middle-aged and elderly women]. / Opyt konservativnogo lecheniia raka molochnoi zhelezy u zhenshchin pozhilogo i preklonnogo vozrasta.

Advantages of conservative treatment of inoperable breast cancer in old and elderly age are discussed on the basis of an analysis of data on 30 cases. A split-course radical radiotherapy was combined with a prolonged tamoxifen treatment. Complete regression of tumor was registered in 16 out of 23 followed-up patients, while more than 50% regression--in I case. The study should be continued.

[Experience in the organization of ambulatory chemotherapy at the All-Union Oncologic Research Center of the USSR Academy of Medical Sciences]. / Opyt organizatsii ambulatornoi khimioterapii vo Vsesoiuznom onkologicheskom nauchnom tsentre AMN SSSR.

The recent advances have made it possible for chemotherapy to be used for cancer control under the conditions of out-patient clinics. Within 5 years, 9,000 out-patients had received at the Center 10-day courses of chemotherapy which was free from toxic complications and produced a therapeutic effect similar to that observed in in-patients. The out-patient chemotherapy service saved 177,140 in-patient/days which is an equivalent of running a 500 bed specialized cancer hospital during 12 months.

[Palliative radiation therapy of malignant tumor metastases to the bones]. / Palliativnaia luchevaia terapiia metastazov zlokachestvennykh opukholei v kosti

The results obtained in irradiation of 106 patients with metastases of different malignant tumors in the skeleton are reported. Radiotherapy was carried out on a distance gamma-apparatus by two fractions, with a single dose of 650 or 850 rad. As a result of the therapy, pains disappeared in 32 patients, and in 60 patients these were diminished considerably. A prompt therapeutic effect of the method, its simplicity and effectiveness (an opportunity to raise the capacity of the apparatus and clinic where a patient stays) made it possible to recommend it for practical purposes of palliative irradiation.

[Chemoradiation therapy of inoperable lung cancer]. / Khimioluchevaia terapiia neoperabel'nogo raka legkogo

The results of utilization of different variants of the complex therapy in 416 patients with inoperable lung cancer are reported. 5-fluoruracil, cyclophosphan, methotrexate, chrysomallin were employed as antitumor drugs. Radiotherapy was carried out on a distance gamma machine. The best immediate and early results were gained in patients treated by distance gammatherapy against the background of cyclophosphan injections. The results proved to be most favourable within the terms of 3 years and longer in case of gammatherapy associated with 5-fluoruracil. Application of a fractionated radiation course rendered no positive effect on the results of treatment.