RESUMO
Twelve clinically sound, healthy, athletically conditioned Thoroughbred horses were subjected to an incremental exercise stress test to determine the effects and period of detection of a single dose of flunixin meglumine (1.1 mg/kg by intravenous injection) in serum and urine by ELISA. Flunixin concentrations, performance, and hematologic and clinical chemical parameters were measured. All horses were rotated through four treatment groups of a Latin-square design providing for each horse to serve as its own control. Flunixin meglumine reduced prostaglandin F(1alpha) and thromboxane concentrations that had been increased by intense exercise. Performance parameters did not improve and prostaglandin concentrations did not significantly correlate with total run time. Exercise did not change the flunixin elimination profile in either serum or urine, and concentrations were found to be below the detection limit of the ELISA test within 36 hours in serum and 120 hours in urine.
Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Clonixina/farmacologia , Cavalos/fisiologia , Condicionamento Físico Animal/fisiologia , Hormônio Adrenocorticotrópico/sangue , Animais , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/sangue , Glicemia , Clonixina/administração & dosagem , Clonixina/análogos & derivados , Clonixina/sangue , Creatinina/sangue , Creatinina/urina , Dinoprostona/sangue , Teste de Esforço/efeitos dos fármacos , Teste de Esforço/veterinária , Feminino , Hidrocortisona/sangue , Injeções Intravenosas/veterinária , Insulina/sangue , Masculino , Consumo de Oxigênio/efeitos dos fármacos , Prostaglandinas/sangue , Prostaglandinas F/sangue , Tromboxano B2/sangue , beta-Endorfina/sangueRESUMO
Following the regimen used to treat equine protozoal myeloencephalitis, sulfadiazine (20 mg/kg) and pyrimethamine (1mg/kg) were administered orally once daily to 12 physically conditioned Thoroughbred horses for 4 consecutive days. The horses were randomly assigned to two test groups in a crossover design, with each horse serving as its own control. A stepwise exercise stress test was conducted to exhaustion. No effect on athletic performance was observed, and only marginal effects were noted in some hematologic and serochemical measurements, including decreased total white blood cell counts, red blood cell distribution width, total hemoglobin, serum sodium, and serum chloride. Serum folic acid concentration decreased significantly following sulfadiazine/pyrimethamine treatment.
