RESUMO
The cellular transplantation in the myocardium or cellular cardiomyoplasty has been tested extensively among the animal. It showed very encouraging results concerning improval of the contractile function in cardiac failure. This work is going to review the set of the experimentations in the animal and the beginnings of the therapeutic tests. It is going to expose the different technical modes that have been proposed, the conditions of their realization, the problems to which they are exposed as well as the perspectives of future.
Assuntos
Isquemia Miocárdica/terapia , Miócitos Cardíacos/transplante , Animais , Modelos Animais de Doenças , Previsões , Hemodinâmica , Humanos , Isquemia Miocárdica/fisiopatologia , Resultado do TratamentoRESUMO
The aim of this study is to evaluate new echocardiographic modes in diagnosis of arrhythmogenic right ventricular dysplasia (ARVD). Our study is prospective, including ten patients with ARVD and a control group of ten healthy subjects. Transthoracic echocardiography included evaluation of classical criteria's, cross sectional measurements of the right ventricular. M mode and pulsed tissue Doppler techniques were used for quantitative measurement of tricuspid annular motion at the lateral and septal positions. Assessed by M mode, the total amplitude of the tricuspid annular motion was decreased in the lateral and septal positions in the patients compared with the controls. The tissue Doppler velocity pattern showed decreased early diastolic peak annular (Ea) velocity and an accompanying decrease in early (Ea) to late diastolic(Aa) velocity ratio in all positions; the systolic annular velocity was decreased only in the lateral position. Tricuspid annular measurement are valuable, easy to obtain and allow quantitative assessment of right ventricular function. ARVC patients showed an abnormal velocity pattern that may be an early but non specific sign of disease.