[The induction of the beta state of the comuton regulation of mitochondrial oxidative phosphorylation by 2,4-DNP and malonate]. / Induktsiia beta-sostoianiia komutonnoi reguliatsii okislitel'nogo fosforilirovaniia mitokhondrii 2,4-DNF i malonatom.

The effect of 2,4-DNP and malonate on tissue-specific uncoupling of oxidative phosphorylation (OP) of rat liver and kidney mitochondria by homologous comutons has been studied. The addition of 2,4-DNP in the presence of comuton induced beta state of comuton regulation. Transfer of liver mitochondria from alpha to beta state also resulted from partial inhibition of succinate dehydrogenase activity of addition of 0.25-0.35 mM malonate. This suggests that the transfer to beta state may be caused by de-energization of mitochondria.

[The effect of a one-time administration of phenobarbital and carbon tetrachloride on comuton activity in the rat liver]. / Vliianie odnokratnogo vvedeniia fenobarbitala i chetyrekhkhloristogo ugleroda na aktivnost' komutona v pecheni krysy.

Infusion of phenobarbital and CCl4 was found to induce comuton control of mitochondrial respiration in a liver of starved rats. Comuton regulation of liver mitochondria respiration can be activated either by increase in liver activity or by damage caused by CCl4. The comuton regulation is directly induced by disturbance of energetic homeostasis of liver cells.