Risk factors of Peyronie's disease. What does our clinical experience show?

INTRODUCTION: Peyronie's disease (PD) is a localized fibrosis that affects the tunica albuginea of the penis. Its origin can be associated with coital penile trauma in men with autoimmune hypersensitivity and a presumed genetic predisposition. AIM: To identify clinical and traumatic risk factors in a patient population with PD, when compared to a control group. METHODS: From November 2007 to March 2010, 317 patients sought medical attention for PD. As control group, 147 consecutive patients, who came for a prostate exam, were studied. Clinical, traumatic, and sexual history of these patients was gathered. Risks factors were considered only if they had been present before the onset of PD symptoms. MAIN OUTCOME MEASURE: The International Index of Erectile Function and the International Prostate Symptoms Score. A univariate logistic regression model (chi-square) (odds ratios [ORs] and 95% confidence intervals [CI]) was used to estimate the association of risk factors with PD; and the Student's t-test was implemented for age. RESULTS: The mean age of patients with PD and control group was 56.7 and 58.8, respectively (P<0.923). The mean evolution time of the disease was 17.7 months (2-48). Erectile dysfunction (ED) and coital trauma constituted the only two independent risk factors for PD compared to the control group (P<0.05 and 0.002, respectively) with an OR of 1.5 (95% CI 1.0-2.3) and 2.69 (95% CI 1.41-5.21), respectively. Patients with ED and diabetes mellitus and with a mild-to-moderate ED also presented a higher predisposition (P=0.008 and 0.00001), with an OR of 3.64 (95% CI 1.33-10.79) and 5.58 (95% CI 3.03-10.42), respectively. CONCLUSION: Erectile dysfunction and coital trauma have proven to be independent risk factors for the development of PD.

Glanuloplasty with urethral flap after partial penectomy.

PURPOSE: We describe a surgical technique to reconstruct the glans secondary to partial penectomy or traumatic partial amputation as well as its complications. We assessed urethral flap vitality and the tumor recurrence rate using this technique. MATERIALS AND METHODS: Glanuloplasty with a urethral flap was done in 10 patients who underwent partial penectomy for penile squamous cell carcinoma. We reconstructed the neoglans with a urethral flap at the same surgical resection. Mean patient age was 61 years (range 18 to 71). Mean followup was 11 months (range 5 to 17). RESULTS: We noted no neomeatal stenosis or flap necrosis secondary to the technique. The early tumor recurrence rate was 10% and the penile curvature rate was 10%. Penile curvature was ventral with no associated penetration difficulty. CONCLUSIONS: This simple, reproducible technique has satisfactory functional and cosmetic results, and an acceptable complication rate for this type of pathological condition.