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The association of thyroid hormone antibodies and glycolipid metabolism indicators with Type 2 diabetes mellitus (T2DM) was explored. As the disease worsens, the levels of thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb), and thyroid-stimulating hormone (TSH) was increased, and the levels of total tri-iodothyronine (TT3) and total thyroxine (TT4) was decreased (P < 0.001). The severe, medium, and light group had higher level of high-density lipoprotein (HDL), lower level of total cholesterol (TC), low-density lipoprotein (LDL), glycosylated hemoglobin (HbA1c), triacylglycerol (TAG), and fasting blood sugar (FBG) than the control group (P ï¼ 0.05). The level of HDL was lower in the severe group than the light group and the medium group, but the levels of TC, LDL, HbA1c, TAG, and FBG were increased with the progress of T2DM (P ï¼ 0.001). The levels of TGAb, TPOAb, and TSH in patients with T2DM were positively correlated with the levels of TC, LDL, HbA1c, TAG, and FBG (P < 0.05), and were negatively correlated with HDL levels (P < 0.05). The life quality score was lower in the severe group than the light and the medium group (P < 0.001). Among the above indicators, the predictive value of TT3, TT4, and HbA1c in T2DM was better. Clinically, detecting the levels of thyroid hormone antibodies and glycolipid metabolism indicators had a certain predictive value for the severity of T2DM. Main findings: The results of this study found that the thyroid hormone antibody and glycolipid metabolism levels in T2DM patients were abnormal, and had different degrees of impact on the quality of life of patients. Thus, monitoring these indicators had certain predictive value for the severity of the disease, and also had a certain degree of suggestive effect on the evaluation of diabetic vascular complications. Clinically, attention should be paid to the screening of thyroid disease in diabetic patients, and the assessment and prognosis of thyroid function on diabetes, the control of diabetes, and the prevention and treatment of complications have important clinical significance.
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Background: Recently, monocyte to high-density lipoprotein cholesterol ratio (MHR) as a novel inflammatory biomarker has drawn lots of attention. This study was conducted in patients with type 2 diabetes mellitus (T2DM) to investigate the correlation between MHR and metabolic-associated fatty liver disease (MAFLD). Methods: Totally, 1,051 patients with T2DM from the Affiliated Hospital of Jiangsu University were enrolled and classified as MAFLD (n = 745) group and non-MAFLD (n = 306) group according to the MAFLD diagnostic criteria. In contrast, patients were also separated into four groups based on MHR quartiles. Anthropometric and biochemical measurements were performed. The visceral fat area (VFA) and subcutaneous fat area (SFA) of participants were measured by dual bioelectrical impedance. Fatty liver was assessed by ultrasonography. Results: The MHR level of subjects in the MAFLD group was statistically greater than that in the non-MAFLD group (P < 0.05). Meanwhile, MHR was higher in the overweight or obese MAFLD group compared with that in the lean MAFLD group (P < 0.05). The area under the ROC Curve (AUC) assessed by MHR was larger than that of other inflammatory markers (P < 0.01). The cutoff value of MHR was 0.388, with a sensitivity of 61.74% and a specificity of 56.54%. For further study, binary logistic regression analyses of MAFLD as a dependent variable, the relationship between MHR and MAFLD was significant (P < 0.01). After adjusting for many factors, the relationship still existed. In the four groups based on MHR quartiles, groups with higher values of MHR had a significantly higher prevalence of MAFLD (P < 0.05). The percentage of patients with obese MAFLD increased as the MHR level increased (P < 0.01). Among different quartiles of MHR, it showed that with the increasing of MHR, the percentage of patients with MAFLD who had more than four metabolic dysfunction indicators increased, which was 46.39, 60.52, 66.79, and 79.91%, respectively, in each quartile. Conclusion: Monocyte to high-density lipoprotein cholesterol ratio is a simple and practicable inflammatory parameter that could be used for assessing MAFLD in T2DM. T2DM patients with higher MHR have more possibility to be diagnosed as MAFLD. Therefore, more attention should be given to the indicator in the examination of T2DM.
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Herein, we studied the adsorption behaviors of organic micropollutants, such as anticonvulsant carbamazepine (CBZ) and antibiotic tetracycline hydrochloride (TC), on zirconium metal-organic framework UiO-66 in water. The maximum adsorption capacities of CBZ and TC on the UiO-66 were 37.2 and 23.1 mg·g-1 at 25 °C, respectively. The adsorption isotherms and kinetics of CBZ and TC were well described by using the Langmuir model and pseudo-second-order model, respectively, and the adsorptions on UiO-66 are endothermic reactions. The adsorption capacities of CBZ and TC on UiO-66 were decreased with the increase of solution pH. The presence of humic acid could improve the adsorption of CBZ and TC on UiO-66, but K+ ion inhibited their adsorption obviously. In addition, Ca2+ and Al3+ ions also suppressed the adsorption of TC on UiO-66. The competitive adsorption suggested that the adsorption sites for CBZ on UiO-66 were different from those for TC. The surface interactions between UiO-66 and the two micropollutants were demonstrated by powder X-ray diffraction, Fourier transform infrared (FT-IR) spectra, scanning electron microscopy, nitrogen adsorption/desorption isotherms, and X-ray photoelectron (XPS) spectra. The characterizations showed that the adsorption of CBZ on UiO-66 is mainly a physisorption, and the hydrophobic effect played a crucial role during the adsorption of CBZ; meanwhile weak π-π electron donor-acceptor interaction and electrostatic attraction also existed. However, the adsorption of TC on UiO-66 is mainly a chemisorption; in addition to the strong electrostatic attraction and π-π electron donor-acceptor interaction forces, the nitrogenous groups of TC played an important role, which can replace the carboxylic groups coordinated with Zr-O clusters. The obtained results will aid us to comprehend the surface interaction between organic micropollutants and UiO-66 and expand the application of UiO-66 as sorbent for removal of pollutants from water.
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Nanoporous adsorbents of ZnO/ZnFe2O4/C were synthesized by using a metal organic framework (Fe(III)-modified MOF-5) as both the precursor and the self-sacrificing template. The adsorption properties of ZnO/ZnFe2O4/C toward Pb(ii) ions were investigated, including the pH effect, adsorption equilibrium and adsorption kinetics. The adsorption isotherms and kinetics were well described by using the Langmuir isotherm model and pseudo-second-order model, respectively. The MOF-derived inorganic adsorbents exhibited high absorption performance with a maximum adsorption capacity of 344.83 mg g(-1). X-ray powder diffraction and high-resolution X-ray photoelectron spectroscopy suggest that Zn(ii) was substituted by a significant portion of Pb(ii) on the surface of ZnO nanocrystals. Microscopic observations also demonstrate the effect of Pb(ii) ions on ZnO crystals as reflected by the considerably reduced average particle size and defective outer layer. Quantitative measurement of the released Zn(ii) ions and the adsorbed Pb(ii) ions indicated a nearly linear relationship (R(2) = 0.977). Moreover, Pb-containing ZnO/ZnFe2O4/C adsorbents are strongly magnetic allowing their separation from the water environment by an external magnet.
