[Accelerated rehabilitation nursing in improving the symptoms of prostate cancer patients after surgery].

OBJECTIVE: To study the clinical value of accelerated rehabilitation nursing (ARN) in improving the symptoms of PCa patients after surgery. METHODS: This study included 80 cases of PCa treated surgically in our hospital from October 2020 to October 2021. We randomly divided the patients into two groups of an equal number to receive ARN and routine nursing care (the control group), respectively. We obtained the scores of the patients on IPSS, TCM syndromes, quality of life (QOL) and pain, incidence of postoperative complications, satisfaction with nursing care and Gleason scores, and compared them between the two groups. RESULTS: The IPSS and TCM syndrome scores were significantly lower (P < 0.05 ), and the physical and psychological function score remarkably higher in the ARN than in the control group (P < 0.05), but there was no statistically significant difference in the social function scores between the two groups (P > 0.05). The postoperative pain score was also significantly lower in the ARN than in the control group (P < 0.05), and so was the incidence rate of postoperative complications (10% vs 37.5%, P < 0.05). The patients' satisfaction with nursing care was markedly higher in the former than in the latter group (90% vs 80%, P < 0.05). No statistically significant difference was observed in the Gleason scores between the two groups of patients. CONCLUSION: Accelerated rehabilitation nursing can effectively improve the symptoms of PCa patients after surgery and therefore deserves clinical application.

Relationship between indium exposure and oxidative damage in workers in indium tin oxide production plants.

PURPOSE: The study aimed to assess the relationship between indium exposure and surfactant protein and any oxidative damage in indium tin oxide (ITO)-exposed workers. METHODS: The study was conducted in two typical ITO-manufacturing plants in Taiwan. One hundred and seventy manufacturing workers and 132 administrators were recruited. RESULTS: The geometric mean serum indium (S-In) level in the workers of the manufacturing department was 1.26 µg/l, which was significantly higher than those in the administrative department (0.72 µg/l). The S-In levels of 49 workers were higher than 3 µg/l (49/302, 16.2%), exceeding an occupational exposure limit suggested by the Japan Society for Occupational Health. Significant positive relationships were found between S-In and surfactant protein A (SP-A), and surfactant protein D (SP-D) levels. SP-A and SP-D levels were elevated significantly in the workers with moderately high indium exposure. CONCLUSION: The present study indicates a significant elevating trend of SP-A and SP-D levels in ITO-manufacturing workers, which are sensitive markers of interstitial lung disease. Though the indium exposure is not directly linked to all indicators of oxidative DNA damage, the ITO-manufacturing workplace is suggested to be related to oxidative DNA damage for the workers in the current study. Therefore, in addition to the indium exposure, there might be other occupational hazards in the ITO workplace to cause oxidative damage.

(µ-Ethane-1,1,2,2-tetra-carboxyl-ato)bis-[tetra-aqua-manganese(II)].

In the centrosymmetric title molecule, [Mn(2)(C(6)H(2)O(8))(H(2)O)(8)], the Mn(II) atom is in an octa-hedral environment coordinated by six O-atom donors from water mol-ecules and ethane-1,1,2,2-tetra-carboxyl-ate ligands. The crystal structure features a three-dimensional hydrogen-bonding network based on a strong and distinctive pattern of O-H⋯O hydrogen-bonding inter-actions.

[Spectroscopic studies on the binding of phenazopyridine hydrochloride and bovine serum albumin].

The binding of phenazopyridine hydrochloride and bovine serum albumin under physiological conditions was studied by spectroscopic method. The quenching mechanism of the fluorescence of bovine serum albumin by phenazopyridine hydrochloride was studied with fluorescence and absorption spectroscopy. The binding constant Kb and the number of binding sites n were determined at different temperatures according to Scatchard equation, and the main binding force was discussed by thermodynamic equations. The effect of the drug on bovine serum albumin conformation was also studied by using synchronous fluorescence spectroscopy. The quenching mechanism of phenazopyridine hydrochloride to bovine serum albumin is static quenching and non-radiation energy transfer. The binding constants Kb at 15, 25 and 37 degrees C are 2.47 x 10(7), 9.15 x 10(6) and 4.36 x 10(6) mol(-1) with one binding site, respectively. The thermodynamic parameters of the reaction are DeltaH = -71.2 kJ x mol(-1), and DeltaS = 124.8 J x mol(-1) x K(-1). Binding phenazopyridine hydrochloride to bovine serum albumin is a spontaneous inter-molecular interaction in which entropy increases and Gibbs free energy decreases. The binding distance r between phenazopyridine hydrochloride and bovine serum albumin is 1.61 nm according to Forster theory of non-radiation energy transfer. The binding force is electrostatic interaction. Phenazopyridine hydrochloride can be deposited and transported by serum protein in vivo. Phenazopyridine hydrochloride does affect the serum protein conformation.

[Spectroscopic studies on the binding of sibutramine hydrochloride and bovine serum albumin].

AIM: To study the binding of sibutramine hydrochloride (SH) and bovine serum albumin (BSA) in physiological condition by spectroscopic method. METHODS: The quenching mechanism of the fluorescence of bovine serum albumin by sibutramine hydrochloride was studied with the fluorescence and the absorption spectroscopy. The binding constants K and the number of binding sites were determined at different temperatures according to Scatchard equation and the main binding force was discussed by thermodynamic equations. The effect of the drug on bovine serum albumin conformation was also studied by using synchronous fluorescence spectroscopy. RESULTS: The quenching mechanism of sibutramine hydrochloride to bovine serum albumin was static quenching. The binding constants K at 8 degrees C, 25 degrees C, 37 degrees C were 1.21 x 10(5), 8.31 x 10(4), 6.97 x 10(4) L x mol(-1) with one binding site, respectively. The thermodynamic parameters of the reaction were deltaH = -9.70 kJ x mol(-1), deltaS = 56.41 J x mol(-1) x K(-1). CONCLUSION: The binding force is electrostatic interaction. Sibutramine hydrochloride can be deposited and transported by serum protein in vivo. Sibutramine hydrochloride has nearly no effect on the serum protein conformation.

[Spectroscopic studies on the binding of prulifloxacin and ct-DNA].

The interaction mechanism of prulifloxacin (PL) and calf thymus DNA (ct-DNA) was studied by UV spectra, fluorescence spectra, and hydrodynamic measurements. The binding of ct-DNA and different concentrations of PL was discussed with UV, FL, phosphate effect and ion strength. The denaturation temperature and viscosity were measured. It is obvious that there is a hypochromic effect on the UV spectra with the fluorescence intensity decreasing regularly after addition of DNA and a red shift of the maximum emission peak with a static quenching constant of 3.1 x 10(4) L x mol(-1). The above results show that a binary complex forms between PL and DNA. It is indicated that there is no static-electro interaction between them by phosphate effect. The outer groove binding is suggested by denaturation temperature of DNA increasing (no more than 7 degrees C) and viscosity slightly decreasing.