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1.
Peking Math J ; 7(1): 1-33, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38444737

RESUMO

In this paper, we study the theory of complements, introduced by Shokurov, for Calabi-Yau type varieties with the coefficient set [0, 1]. We show that there exists a finite set of positive integers N, such that if a threefold pair (X/Z∋z,B) has an R-complement which is klt over a neighborhood of z, then it has an n-complement for some n∈N. We also show the boundedness of complements for R-complementary surface pairs.

2.
Nan Fang Yi Ke Da Xue Xue Bao ; 34(8): 1171-5, 2014 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-25176089

RESUMO

OBJECTIVE: To observe the effect of N-acetylcysteine (NAC) on intestine injury induced by cardiopulmonary bypass (CPB) in rats. METHODS: Thirty-two rats were randomly divided into sham-operated group, NAC control group, CPB model group, and CPB plus NAC treatment group (n=8). In the latter two groups, the rats were subjected to CPB for 1 h. The rats received intraperitoneal injections of normal saline or NAC (0.5 g/kg) as appropriate for 3 successive days prior to CPB, and those in CPB plus NAC group were given NAC (100 mg/kg) in CPB prime followed by infusion at 20 mgsol;(kg·h) until the cessation of CPB. Intestinal and blood samples were collected 2 h after CPB for pathological analysis and measurement of intestinal concentrations of malondialdehyde (MDA), tumor necrosis factor (TNF)-α, interlukin (IL)-6 and activity of superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px) and serum levels of diamine oxidase (DAO). RESULTS: Evident oxidative stress and pathological damages of the intestines were observed in rats after CPB. NAC treatment obviously alleviated intestinal damages induced by CPB, decreased the levels of intestinal MDA, TNF-α, IL-6 and serum DAO and increased activity of SOD, GSH, and GSH-Px in the intestines. CONCLUSION: Perioperative NAC treatment can alleviate intestinal injury induced by CPB in rats by suppressing oxidative stress and inflammatory response.


Assuntos
Acetilcisteína/farmacologia , Ponte Cardiopulmonar/efeitos adversos , Intestinos/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Animais , Glutationa/metabolismo , Glutationa Peroxidase/metabolismo , Inflamação/tratamento farmacológico , Interleucina-6/metabolismo , Intestinos/fisiopatologia , Malondialdeído/metabolismo , Ratos , Superóxido Dismutase/metabolismo , Fator de Necrose Tumoral alfa
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