RESUMO
It is highly desirable to develop a therapeutic, observable nanoparticle complex for specific targeting in cancer therapy. Growth hormone (GH) and its antagonists have been explored as cancer cell-targeting molecules for both imaging and therapeutic applications. In this study, a low toxicity, biocompatible, therapeutic, and observable GH-nanoparticle complex for specifically targeting growth hormone receptor (GHR) in cancer cells was synthesized by conjugating GH with green fluorescence protein and carboxylated nanodiamond. Moreover, we have shown that this complex can be triggered by laser irradiation to create a "nanoblast" and induce cell death in the A549 non-small-cell lung cancer cell line via the apoptotic pathway. This laser-mediated, cancer-targeting platform can be widely used in cancer therapy.
Assuntos
Antineoplásicos/química , Antineoplásicos/farmacologia , Materiais Biocompatíveis/farmacologia , Hormônio do Crescimento/química , Nanodiamantes/química , Neoplasias/tratamento farmacológico , Receptores da Somatotropina/antagonistas & inibidores , Antineoplásicos/síntese química , Materiais Biocompatíveis/síntese química , Materiais Biocompatíveis/química , Morte Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Proteínas de Fluorescência Verde/química , Humanos , Lasers , Estrutura Molecular , Neoplasias/patologia , Tamanho da Partícula , Relação Estrutura-Atividade , Succinimidas/química , Propriedades de SuperfícieRESUMO
Vertically aligned gallium nitride (GaN) nanorod arrays grown by the catalyst-free, self-organized method based on plasma-assisted molecular-beam epitaxy are shown to behave as subwavelength optical media with low effective refractive indices. In the reflection spectra measured in the entire visible spectral region, strong reflectivity modulations are observed for all nanorod arrays, which are attributed to the effects of Fabry-Pérot microcavities formed within the nanorod arrays by the optically flat air/nanorods and nanorods/substrate interfaces. By analyzing the reflectivity interference fringes, we can quantitatively determine the refractive indices of GaN nanorod arrays as functions of light wavelength. We also propose a model for understanding the optical properties of GaN nanorod arrays in the transparent region. Using this model, good numerical fitting can be achieved for the reflectivity spectra.
Assuntos
Desenho Assistido por Computador , Tecnologia de Fibra Óptica/instrumentação , Gálio/química , Interferometria/instrumentação , Modelos Teóricos , Nanotubos/química , Nanotubos/ultraestrutura , Refratometria/instrumentação , Simulação por Computador , Desenho de Equipamento , Análise de Falha de Equipamento , Nanotubos/efeitos da radiação , Refratometria/métodosRESUMO
Epitaxial AlN films have been grown on GaN/sapphire using helicon sputtering at 300 degrees C. The surface acoustic wave (SAW) filters fabricated on AlN/GaN/sapphire exhibit more superior characteristics than those made on GaN/sapphire. This composite structure of AlN on GaN may bring about the development of high-frequency components, which integrate and use their semiconducting, optoelectronic, and piezoelectric properties.
RESUMO
We introduce a graphic method for analyzing a periodically stratified multilayer omnidirectional reflector. When the dispersive refractive indices of the materials are known, the contours of constant omnibandwidth and constant center wavelength with respect to layer thickness can be numerically and graphically presented for analysis. Examples of this procedure for TiO2/SiO2 and Si/SiO2 periodically layered systems for the visible and near-infrared regions are given. A comparison of omnidirectional reflectors of quarter-wave and non-quarter-wave layer thicknesses is made by the graphic method.
