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1.
Cancer Manag Res ; 13: 8809-8819, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34866939

RESUMO

PURPOSE: Hyperuricemia and metabolic syndrome (MetS) have been shown to correlate with prognosis in patients with malignant tumors. The present study evaluated the relationship between preoperative hyperuricemia and MetS in colorectal cancer (CRC) patients and analyzed the effect of this combination on prognosis within 5 years. PATIENTS AND METHODS: The study enrolled patients who had undergone radical CRC resection at three independent medical centers from January 2014 to December 2016. Patients were preoperatively categorized into four groups, those with hyperuricemia alone (H), those with MetS alone (MS), those with MetS-related hyperuricemia (MSH), and those with neither condition (control [C] group). The disease-free survival (DFS) and overall survival (OS) rates of these four groups were compared. RESULTS: The study population consisted of 1271 patients, with 114, 201, 101, and 855 patients categorized into the H, MS, MSH and C groups, respectively. Preoperative MetS was found to be significantly associated with hyperuricemia (P < 0.001). Multivariate Cox regression analysis showed that MetS-related hyperuricemia (hazard ratio [HR] = 2.728; P < 0.001) and MetS alone (HR = 1.631; P < 0.001) were independent predictors of death, whereas simple hyperuricemia was not (P > 0.1). Relative to the C group, the MSH group had the highest rate of tumor recurrence or metastasis (HR = 5.103, P < 0.001), followed by the MS (HR = 2.231, P < 0.001) group. In contrast, prognosis did not differ significantly in the H and C groups (P > 0.1). MetS was significantly associated with poor prognosis, with MetS-related hyperuricemia resulting in a significantly poorer prognosis. In contrast, hyperuricemia alone had no effect on the long-term prognosis of CRC patients. CONCLUSION: This study highlights the prognostic importance of MetS-related hyperuricemia on the survival of patients with CRC.

2.
Physiol Behav ; 171: 236-242, 2017 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-28108331

RESUMO

The Doppler-shift compensation (DSC) behavior of constant frequency - frequency modulation (CF-FM) bat (Hipposideros pratti) is vital for extraction and analysis of echo information. This type of behavior affects the recovery cycles of sound-sensitive neurons, but their precise relationship remains unclear. In this study, we investigated the effects of DSC on the recovery cycles of inferior collicular (IC) neurons in H. pratti. We simulated the pulse-echo pair in bats by changing the emitted pulse frequency and keeping the echo frequency constant during DSC in echolocation. The neuronal recovery cycles of IC neurons are categorized into four types: unrecovered, monotonic, single-peak, and multi-peak. The recovery cycle of IC neurons shortens after DSC; moreover, the amount of neurons with multi-peak recovery cycle increases and concentrates in the short recovery area. This paper also discusses the possible neural mechanisms and their biological relevance to different phases of bat predation behavior.


Assuntos
Potenciais de Ação/fisiologia , Percepção Auditiva/fisiologia , Ecolocação/fisiologia , Colículos Inferiores/citologia , Neurônios/fisiologia , Som , Estimulação Acústica , Análise de Variância , Animais , Quirópteros/fisiologia , Recuperação de Função Fisiológica
4.
Carbohydr Polym ; 111: 298-304, 2014 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-25037355

RESUMO

Paclitaxel (PTX) loaded multilayered liposomes were prepared using layer-by-layer assembly in an effort to improve the stabilization of the liposomal compositions for PTX delivery. Stearyl amine was used to provide positive charge to the PTX-liposomes, and subsequently coated with anionic polyacrylic acid (PAA) followed by cationic chitosan. Various process variables were optimized and the optimum formulation was found to have particle size of 215 ± 17 nm, zeta potential of +27.9 ± 3.4 mV and encapsulation efficiency of 70.93 ± 2.39%. The lyophilized chitosan-PAA-PTX-liposomes formulation was stable in simulated gastrointestinal fluids and at different environmental conditions (4 °C and 25 °C). In vitro drug release experiments demonstrated that chitosan-PAA-PTX-liposomes formulation exhibited obvious sustained release behaviors compared to PTX-liposomes. Furthermore, chitosan-PAA-PTX-liposomes formulation revealed enhanced PTX induced cytotoxicity in human cervical cancer cell culture experiments compared to PTX-liposomes. In conclusion, the approach presented herein will provide a promising solution for PTX delivery.


Assuntos
Antineoplásicos Fitogênicos/administração & dosagem , Quitosana/química , Sistemas de Liberação de Medicamentos , Paclitaxel/administração & dosagem , Neoplasias do Colo do Útero/terapia , Resinas Acrílicas/química , Linhagem Celular Tumoral , Quitosana/toxicidade , Colesterol/química , Feminino , Humanos , Lipossomos , Fosfolipídeos/química , Temperatura
5.
Zhongguo Zhong Yao Za Zhi ; 38(21): 3731-5, 2013 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-24494563

RESUMO

OBJECTIVE: To observe the effect of Taohong Siwu decoction (THSWD) on micro-vascular density (MVD) in rat uterus, the content of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) in serum, and the expression of tyrosine kinasa receptor (Tie-2) in uterus. METHOD: Early pregnancy rats were intragastrically administrated with misoprostol (100 microg x kg(-1)) and mifepristong (8.3 mg x kg(-1)) to established the incomplete-abortion model. The incomplete-abortion rats were randomly divided into the model group (the same volume of distilled water), the positive control group (at the daily dose of 4.3 g x kg(-1) Motherwort Particles), and THSWD-treated groups (at the daily dose of 18.0, 9.0 and 4.5 g x kg(-1)). Pregnant rats were taken as the control group (the same volume of distilled water). After the successive oral administration for 7 days, blood was collected from aorta abdominalis, and rat uterine tissues were collected. The content of serum Ang-1 and Ang-2 were detected by ELISA; And the levels of Tie-2 and MVD in uterine tissues were detected by SP immunohistochemistry. RESULT: THSWD remarkably increased the levels of MVD in uterus of medicine-induced abortion rats, the content of Ang-1 and Ang-2 in serum, and the expression of Tie-2 in uterine tissues. CONCLUSION: THSWD has the effect in markedly promoting angiogenesis in incomplete-abortion rats. Its mechanism may be related to the regulation of concentrations of Ang-1 and Ang-2 in serum and Tie-2 in uterine tissues.


Assuntos
Aborto Incompleto/tratamento farmacológico , Aborto Incompleto/genética , Angiopoietina-1/genética , Angiopoietina-2/genética , Medicamentos de Ervas Chinesas/uso terapêutico , Receptor TIE-2/genética , Útero/irrigação sanguínea , Aborto Incompleto/sangue , Angiopoietina-1/sangue , Angiopoietina-2/sangue , Animais , Feminino , Expressão Gênica/efeitos dos fármacos , Humanos , Gravidez , Ratos , Ratos Sprague-Dawley , Receptor TIE-2/metabolismo , Útero/efeitos dos fármacos , Útero/metabolismo
6.
J Bacteriol ; 193(1): 315-6, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21037005

RESUMO

Ketogulonicigenium vulgare is characterized by the efficient production of 2KGA from L-sorbose. Ketogulonicigenium vulgare Y25 is known as a 2-keto-L-gulonic acid-producing strain in the vitamin C industry. Here we report the finished, annotated genome sequence of Ketogulonicigenium vulgare Y25.


Assuntos
Genoma Bacteriano , Rhodobacteraceae/genética , Dados de Sequência Molecular , Rhodobacteraceae/classificação
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