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1.
Artigo em Chinês | MEDLINE | ID: mdl-22590860

RESUMO

OBJECTIVE: To study the function of interleukin-33 (IL-33) in the development of human acute schistosomiasis japonica by determining the serum IL-33 levels in acute schistosomiasis japonica patients. METHODS: Four patients with acute schistosomiasis japonica were recruited from schistosomiasis endemic lake areas, and 15 controls were recruited outside the schistosomiasis endemic areas. The demographic data and venous blood were collected from all the subjects. The serum IL-33 levels of all the subjects were tested by using enzyme-linked immunosorbent assay. All the results were statistically analyzed with Stata 10.0 software. RESULTS: The serum IL-33 levels of the patients with acute schistosomiasis japonica [517.33 (334.65, 1 056.88) pg/ml] were significantly higher than those of the controls [1.66(1.66, 6.35) pg/ml] (Z = -3.207, P = 0.001). The correlation coefficients between serum IL-33 levels and numbers of eosinophils, serum IL-33 levels and duration of infection were both 0.8 (P = 0.2). CONCLUSIONS: The serum IL-33 level is significantly elevated in the patients with acute schistosomiasis japonica, indicating that IL-33 may play a pro-inflammatory role in the acute stage of schistosomiasis japonica and participate in initiating the Th2 type immune responses between 7 and 9 weeks after the infection.


Assuntos
Interleucinas/sangue , Esquistossomose Japônica/sangue , Doença Aguda , Adolescente , Adulto , Criança , Feminino , Humanos , Interleucina-33 , Interleucinas/imunologia , Masculino , Pessoa de Meia-Idade , Esquistossomose Japônica/diagnóstico , Esquistossomose Japônica/imunologia , Adulto Jovem
2.
Zhonghua Liu Xing Bing Xue Za Zhi ; 30(8): 761-5, 2009 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-20193193

RESUMO

OBJECTIVE: To study the relationship between dietary soy isoflavones and blood lipids among residents of 40 - 65 years old, in Guangzhou. METHODS: Dietary soy isoflavones and other nutrients intakes were assessed with quantitative food frequency questionnaire (FFQ). Total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) in plasma were measured with colorimetry. RESULTS: Ranges of dietary soy isoflavones intake among 134 males and 261 females were from 0 mg/day to 61.96 mg/day and 0 mg/day to 82.52 mg/day, with means of 11.95 mg/day, 14.90 mg/day, respectively. After adjusted for total energy intake and fat percent energy, differences of TC, LDL-C in total population and TC in women were statistically significant between groups (P value was 0.002, 0.008, 0.004, respectively) and dose-effect relationships (P value was < 0.001, 0.012, 0.001, respectively) were observed between dietary soy isoflavones intake and the upper mentioned three indices. Compared with the low-intake group, these three indices lowered 7.06%, 10.13% and 7.48%, respectively in high-intake group. Critical significance of LDL-C was observed both in women and men between groups. Further controlled for age, BMI and WHR, no obvious change of the results was observed. CONCLUSION: Moderate intakes of soy isoflavone as part of a regular diet seemed to be associated with favorable blood lipid levels.


Assuntos
Colesterol/sangue , Dieta , Glycine max , Isoflavonas/administração & dosagem , Triglicerídeos/sangue , Adulto , Idoso , China , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Colorimetria , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores Sexuais
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