Single-Cell Chromatin Accessibility Analysis Reveals Subgroup-Specific TF-NTR Regulatory Circuits in Medulloblastoma.

Medulloblastoma (MB) stands as one of the prevalent malignant brain tumors among pediatric patients. Despite its prevalence, the intricate interplay between the regulatory program driving malignancy in MB cells and their interactions with the microenvironment remains insufficiently understood. Leveraging the capabilities of single-cell Assay for Transposase-Accessible Chromatin sequencing (scATAC-seq), the chromatin accessibility landscape is unveiled across 59,015 distinct MB cells. This expansive dataset encompasses cells belonging to discrete molecular subgroups, namely SHH, WNT, Group3, and Group4. Within these chromatin accessibility profiles, specific regulatory elements tied to individual subgroups are uncovered, shedding light on the distinct activities of transcription factors (TFs) that likely orchestrate the tumorigenesis process. Moreover, it is found that certain neurotransmitter receptors (NTRs) are subgroup-specific and can predict MB subgroup classification when combined with their associated transcription factors. Notably, targeting essential NTRs within tumors influences both the in vitro sphere-forming capability and the in vivo tumorigenic capacity of MB cells. These findings collectively provide fresh insights into comprehending the regulatory networks and cellular dynamics within MBs. Furthermore, the significance of the TF-NTR regulatory circuits is underscored as prospective biomarkers and viable therapeutic targets.

A new species of the genus Xya Latreille, 1809 from Fujian, China (Orthoptera, Tridctyloidea, Tridactylidae).

The genus Xya Latreille, 1808 obtains 58 known species in the world, among them 18 species distributed in Asia and 8 species in China only i.e. Xya japonica (Haan, 1842), Xya riparia (Saussure, 1877), Xya nitobei (Shiraki, 1911), Xya apicicornis (Chopard, 1928), Xya manchurei Shiraki, 1936, Xya lehsanensis Cao et al, 2017, Xya sichuanensis Cao et al, 2018, Xya shandongensis, Zhang et al, 2018; [Latreille, 1809; Haan, 1844; Walker, 1871; Saussure, 1877, 1896; Brunner von Wattenwyl. 1893; Bolivar, 1900(1899); Shiraki,1911, 1936; Chopard, 1920, 1928, 1936, 1968; Tindale, 1928; Willemse, 1954; Bey-Bienko, 1967; Harz, 1970, 1971; Günther, 1974, 1978, 1980, 1982, 1990, 1995, 1998; Ingrisch, 1987, 2006; Baehr, 1988; Yin et al, 1996; Murai, 2005; Yin et al, 2013; Heads Hollier, 2016; Kuravova Kocarek, 2016; Cao et al, 2017; Cao et al, 2018; Zhang et al, 2018; Cigliano, et al, 2019]. In the present paper, a new species of the genus Xya Latreille, 1809 from Fujian, China is described. The new species Xya fujianensis sp. nov. is similar to Xya lehsanensis Cao et al, 2017, but differs from the latter by head black, with a yellow band along inner margin of eye; pronotum black, with a white band on the lower margin; fore wing black, with two yellow spots near base and two yellow spots near top and hind femur black with two large yellow spots on upper side. Type specimens are deposited in the College of Life Science, Leshan Normal University, Leshan 614004, China.

A new genus and a new species of pygmy mole cricket in Cretaceous amber from Burma (Orthoptera: Tridactylidae).

A new genus and a new species of pygmy mole cricket i.e. Paraxya gen nov. and Paraxya hui sp. nov. are described from Burma Cretaceous amber in this paper. The new genus is allied to Xya Latreille. 1809, but differs from latter by lacking swimming plates at metatibia [Latreille. 1809; Yin et al, 1996; Cao et al, 2017, Cao et al, 2018 and Zhang et al, 2018]. The new genus is also allied to Burmadactylus Heads, 2009, but differs from latter by metatarsus absent and hindwing present, surpassing the end of abdomen distinctly [Heads, 2009]. Type specimen is deposited in the College of Life Science, Leshan Normal University, Leshan 614004, China.

Description of a new species of the genus Mongolotettix Rehn, 1928 (Orthoptera: Acrididae) from Fujian, China.

A new species of the genus Mongolotettix Rehn, 1928 from Fujian, China is described in this paper. The new species Mongolotettix.fujianensis sp. nov. is similar to M. wulingyuanensis Shi, Liu et Li, 2016, but differs from the latter by maximum width of cubital area 1.4 times maximum width of medial area in tegmina of male; body small, length of body ♂ 21.5. mm, ♀ 30.6 mm; vertical diameter eye 1.3 times horizontal diameter in male; hind femur of male with 103 stridulatory pegs on inner side and epiphallus with indistinct projection on inner side of lateral plates. Type specimens are deposited in the Shanghai Entomological Museum, Chinese Academy of Sciences, Shanghai, 200032, China.