The Longitudinal Dyadic Associations Between Social Participation and Cognitive Function in Older Chinese Couples.

OBJECTIVES: Based on the "linked lives" tenant of the life course perspective, this longitudinal study aims to examine the actor and partner effects of social participation on cognitive function in older Chinese couples. METHODS: A total of 1,706 couples aged 60 and older were included in the final analyses. Social participation was measured using 2 questions regarding types of activities and frequency. Cognitive function was measured using a combination of memory, orientation, visuoconstruction, attention, and calculation. The lagged-dependent APIM was used to model the dyadic associations between social participation and cognitive function. RESULTS: The time-averaged actor effects of both husbands' and wives' social participation on their own cognitive function were significant (p < .001 for both). The time-averaged partner effect of husbands' social participation on wives' cognitive function was significant (p < .001) but the reverse-the effect of wives' social participation on husbands' cognitive function-was not (p = .381). The time-specific actor and partner effects were not significant (p > .05 for all). DISCUSSION: Our findings indicate an asymmetrical pattern of actor-partner interdependence, where husbands' social participation may affect their wives' cognitive function on average, but wives' social participation does not affect their husbands' cognitive function. Clinical practitioners should invite both partners, especially husbands, to participate in social participation interventions to facilitate crossover benefits for wives. Moreover, policymakers should build more facilities to encourage older couples to engage in social activities to prevent cognitive decline.

Physical activity, physical frailty and depressive symptoms among Chinese male and female older adults: do different indicators make a difference?

Objectives: Older adults become more inactive and frailer with aging. Physical status is closely linked to mental health, but it is unclear which physical indicator is more strongly associated with depressive symptoms in older adults. The present study aimed to compare relationships between self-reported physical activity, physical frailty (muscle mass, muscle strength, and gait ability) and depressive symptoms in community male and female older adults. Methods: A total of 1,180 adults aged 60 years and older were recruited to participate in this study from a Chinese community receiving annual check-up service from September 2018 to May 2019. Physical activity was assessed by the International Physical Activity Questionnaire (IPAQ). The Bio-electrical Impedance Analyzer was used to determine the muscle mass. As the indicators of muscle function, grip strength and gait ability were assessed by the dynamometer and Timed Up and Go Test (TUGT), respectively. The 15-item version of Geriatric Depression Scale (GDS-15) was used to examine depressive symptoms. Demographic variables, health status and sleep quality were collected using questionnaire. Results: 11.8% men and 11.9% women reported depressive symptoms. Logistic regression showed that depressive symptoms was associated with low grip strength (OR = 2.42, 95% CI: 1.04-5.63), slow gait ability (OR = 3.60, 95% CI: 1.28-10.13) in older males, and associated with low level of self-reported physical activity (OR = 3.85, 95% CI: 2.00-7.42) in older females. No significant association was found between muscle mass and depressive symptoms. Conclusion: There were gender differences in the relationship between physical activity, physical frailty, and depressive symptoms. Grip strength and gait ability may be a better indicator of frailty for predicting depressive symptoms in older men while physical activity may be useful in predicting depressive symptoms in older women.

Perceived Control, Control Strategies, and Subjective Well-being in the Elderly: A Longitudinal Study of Health Behavior.

Objectives: We analyzed the directional effect of perceived control and control strategies on subjective well-being in middle-aged and elderly people with historical data, and to provide data support for the intervention of well-being in the later years of the elderly group, so as to help them age successfully.Methods: Using data from the CLHLS between 2005 and 2014, we collected demographic and social data of the same elderly population over the decade. We also gathered information on changes in well-being, perceived control, and the use of control strategies. To analyze the longitudinal relationship between subjective well-being and perceived control, including the impact of control strategies on subjective well-being, we used a multilevel growth model with MPLUS. Results: We found that subjective well-being and perceived control were not affected by time. However, changes in perceived control in older adults could predict their level of subjective well-being. Those with higher initial levels of perceived control experienced greater increases in subjective well-being. Additionally, the use of control strategies had a significant influence on changes in subjective well-being, explaining 70.5% of the variance. Conclusion: Combined use of multiple control strategies is a feasible way to improve subjective well-being in later life.

Mn-XRN1 Has an Inhibitory Effect on Ovarian Reproduction in Macrobrachium nipponense.

XRN1 is an exoribonuclease that degrades mRNA in the cytoplasm along the 5'-3' direction. A previous study indicated that it may be involved in the reproduction of Macrobrachium nipponense. Quantitative real-time PCR was used to detect the spatiotemporal expression pattern of Mn-XRN1. At the tissue level, Mn-XRN1 was significantly expressed in the ovary. During development, Mn-XRN1 was significantly expressed at the CS stage of the embryo, on the 10th day post-larval and in the O2 stage of ovarian reproduction. The in situ hybridization results showed the location of Mn-XRN1 in the ovary. The expression of Mn-VASA was significantly increased after in vivo injection of Mn-XRN1 dsRNA. This suggests that Mn-XRN1 negatively regulates the expression of Mn-VASA. Furthermore, we counted the number of M. nipponense at various stages of ovarian reproduction on different days after RNAi. The results showed that ovarian development was significantly accelerated. In general, the results of the present study indicate that Mn-XRN1 has an inhibitory effect on the ovarian maturation of M. nipponense. The inhibitory effect might be through negative regulation of Mn-VASA.

Intergenerational support and depressive symptoms in old age: The difference between urban and rural China.

Objectives: Intergenerational support is associated with fewer depressive symptoms in old age. Uneven development has resulted in huge urban-rural disparities in China, which could lead to different intergenerational relationships. The present study aimed to examine whether intergenerational support was associated with depressive symptoms differently among urban and rural Chinese older participants. Methods: A sample of 3,498 participants from nine pairs of urban subdistricts and rural villages were included in the present study. Depressive symptoms were measured by the 10-item Center for Epidemiological Studies Depression Scale, and the intergenerational support mechanisms (financial, instrumental, and emotional) were assessed with a self-designed questionnaire. Results: Significant areas by support effect for depressive symptoms indicated different associations between intergenerational financial and emotional support and depressive symptoms in urban and rural areas. Specifically, urban older participants receiving emotional support from adult children and rural older participants receiving financial support from adult children showed fewer depressive symptoms. In both areas, participants receiving instrumental support showed fewer depressive symptoms. Conclusion: Our study is the first to compare the urban-rural disparity in association between intergenerational support and depressive symptoms in a developing country, China. The results support modernization theories proposing weakened economic function but intensified emotional ties in societies with higher level of development. Communication-based intergenerational emotional support should be promoted in urban areas, and formal support systems should provide financial and instrumental support to the vulnerable rural older population.

RNA interference analysis of potential functions of cyclin A in the reproductive development of male oriental river prawns (Macrobrachium nipponense).

Cyclin A (CycA) plays essential roles in regulating multiple steps of the cell cycle, and it affects gonad development in mammals and invertebrates. Previous RNA interference (RNAi) analysis revealed that knocking-down the expression of CycA in female oriental river prawns (Macrobrachium nipponense) inhibited ovarian development. CycA was also predicted to have regulatory roles in reproductive development of male M. nipponense based on significant changes of Mn-CycA expression after eyestalk ablation. The goal of this study was to investigate the potential functions of CycA in the reproductive development of male M. nipponense using RNAi and histological observations. Quantitative real-time PCR analysis revealed that both single-side and double-side eyestalk ablation stimulated the expressions of Mn-CycA, and the expression was higher in prawns with double-side eyestalk ablation (p < 0.05). Mn-CycA expression was significantly higher in the testis and androgenic gland during the reproductive season than during the non-reproductive season (p < 0.05). In the RNAi analysis, Mn-CycA expression significantly decreased after prawns were injected with dsCycA, and the expression of insulin-like androgenic gland hormone (Mn-IAG) also decreased as Mn-CycA expression decreased. This result indicated that CycA positively regulated the expression of IAG in M. nipponense. Histological observations revealed that the number of sperm decreased dramatically to <5% of the total cells in the testis of the dsCycA-treated group compared to that of control group on day 14, indicating that knockdown of Mn-CycA expression inhibited testis development by affecting the expression of Mn-IAG in M. nipponense. These results highlighted the functions of CycA in male reproductive development of M. nipponense, which can be applied to future studies of male reproduction in other crustacean species.

RNA Interference Analysis of the Functions of Cyclin B in Male Reproductive Development of the Oriental River Prawn (Macrobrachium nipponense).

Cyclin B (CycB) plays essential roles in cell proliferation and promotes gonad development in many crustaceans. The goal of this study was to investigate the regulatory roles of this gene in the reproductive development of male oriental river prawns (Macrobrachium nipponense). A phylo-genetic tree analysis revealed that the protein sequence of Mn-CycB was most closely related to those of freshwater prawns, whereas the evolutionary distance from crabs was much longer. A quantitative PCR analysis showed that the expression of Mn-CycB was highest in the gonad of both male and female prawns compared to that in other tissues (p < 0.05), indicating that this gene may play essential roles in the regulation of both testis and ovary development in M. nipponense. In males, Mn-CycB expression in the testis and androgenic gland was higher during the reproductive season than during the non-reproductive season (p < 0.05), implying that CycB plays essential roles in the reproductive development of male M. nipponense. An RNA interference analysis revealed that the Mn-insulin-like androgenic gland hormone expression decreased as the Mn-CycB expression decreased, and that few sperm were detected 14 days after the dsCycB treatment, indicating that CycB positively affects testis development in M. nipponense. The results of this study highlight the functions of CycB in M. nipponense, and they can be applied to studies of male reproductive development in other crustacean species.

Transcriptome analysis provides novel insights into the immune mechanisms of Macrobrachium nipponense during molting.

Molting is a basic physiological behavior of the Oriental river prawn (Macrobrachium nipponense), however, the gene expression patterns and immune mechanisms during the molting process of Oriental river prawn are unclear. In the current study, the gene expression levels of the hepatopancreas of the Oriental river prawn at different molting stages (pre-molting, Prm; mid-molting, Mm; and post-molting, Pom) were detected by mRNA sequencing. A total of 1721, 551, and 1054 differentially expressed genes (DEGs) were identified between the Prm hepatopancreas (PrmHe) and Mm hepatopancreas (MmHe), MmHe and Pom hepatopancreas (PomHe) and PrmHe and PomHe, respectively. The results showed that a total of 1151 DEGs were annotated into 316 signaling pathways, and the significantly enriched immune-related pathways were "Lysosome", "Hippo signaling pathway", "Apoptosis", "Autophagy-animal", and "Endocytosis". The qRT-PCR verification results of 30 randomly selected DEGs were consistent with RNA-seq. The expression patterns of eight immune related genes in different molting stages of the Oriental river prawn were analyzed by qRT-PCR. The function of Caspase-1 (CASP1) was further investigated by bioinformatics, qRT-PCR, and RNAi analysis. CASP1 has two identical conserved domains: histidine active site and pentapeptide motif, and the expression of CASP1 is the highest in ovary. The expression levels of triosephosphate isomerase (TPI), Cathepsin B (CTSB) and Hexokinase (HXK) were evaluated after knockdown of CASP1. This research provides a valuable basis to improve our understanding the immune mechanisms of Oriental river prawns at different molting stages. The identification of immune-related genes is of great significance for enhancing the immunity of the Oriental river prawn, or other crustaceans, by transgenic methods in the future.

Can working memory capacity be expanded by boosting working memory updating efficiency in older adults?

Working memory updating (updating) and working memory capacity (WMC) have been assumed to share a common mechanism. However, it is unclear whether WMC can be expanded by boosting the efficiency of updating, particularly during late adulthood. In this randomized controlled study, 33 older adults (aged 60 years and above, M = 69.53, SD = 5.21) were assigned to updating training (n = 17) and contact control (n = 16) groups. In the training group, updating was targeted by a running memory task and a chess game in each training session; whereas in the control group, motivational effects were estimated by their attendance to a series of mental health-related lectures. The boosted updating efficiency was demonstrated by direct training gains over sessions on updating criterion/training tasks, and significant frontocentral inflation at the N2 time range. Near transfer effects were revealed on untrained similar measures immediately after training and partly maintained at a 3-month follow-up. Far transfer effects to WMC were revealed by a significant increase in contralateral delay activity (CDA) ERP measures, although these effects did not manifest on WMC span tasks and other far transfer measures. Note that increased CDA was significantly correlated with the extent of direct gains in updating training. Our findings suggest that updating efficiency can be boosted in older adults; although it has not yet brought about an explicit expansion of WMC in our behavioral measures (i.e., on span tasks), capacity-related neural changes (i.e., on CDA) have nevertheless, started to show up in our short-term updating training program. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Plasticity in older adults' theory of mind performance: the impact of motivation.

OBJECTIVE: Recently, motivation has been found to attenuate the age-related decline in Theory of Mind (ToM) performance (i.e. faux pas recognition). However, whether or not this effect could be generalized to other ToM tasks is still unknown. In the present study, we investigated whether and how motivation could enhance older adults' performance and reduce age differences in ToM tasks (Faux Pas vs. Animation task) that differ in familiarity. METHOD: Following a previous paradigm, 171 Chinese adults (87 younger adults and 84 older adults) were recruited, and we experimentally manipulated the level of perceived closeness between participants and the experimenter before administering the ToM tasks in order to enhance participants' motivation. RESULTS: Results showed that, for the Faux Pas task, we replicated previous findings such that older adults under the enhanced motivation conditions performed equally well as younger adults. Conversely, for the Animation task, younger adults outperformed older adults, regardless of motivation. DISCUSSION: These results indicate that motivation can enhance older adults' performance in ToM tasks, however, this beneficial effect cannot be generalized across ToM tasks.

Polarization-dependent strong coupling between surface plasmon polaritons and excitons in an organic-dye-doped nanostructure.

In this work, we demonstrate polarization-dependent strong coupling between surface plasmon polaritons (SPPs) and excitons in the J-aggregates-attached aperture array. It is shown that the excitons strongly couple with the polarization-dependent SPPs, and Rabi splittings are consequently observed. As a result, the polarization-dependent polariton bands are generated in the system. Increasing the incident angle, the polaritons disperse to higher energies under transverse-electric illumination, while the polaritons disperse to lower energies under transverse-magnetic illumination. Therefore, at different polarization incidence, we experimentally achieve distinct polaritons with opposite dispersion directions. In this way, tuning the polarization of the incident light, we can excite different polaritons whose energy propagates to different directions. Furthermore, by retrieving the mixing fractions of the components in these polariton bands, we find that the dispersion properties of the polaritons are inherited from both the SPPs and the excitons. Our investigation may inspire related studies on tunable photon-exciton interactions and achieve some potential applications on active polariton devices.

Dielectric lens guides in-plane propagation of surface plasmon polaritons.

In this work, we present in-plane propagation of surface plasmon polaritons (SPPs) guided by a single dielectric (Al2O3) subwavelength lens. By mounting a designed Al2O3 nanoparticle on the silver film, the effective index of a silver-Al2O3 interface is influenced by the particle thickness, then the phase difference between the silver-air and silver-Al2O3 interface can be utilized to modulate the in-plane propagation of SPPs. We show that an elliptical Al2O3 lens transforms the diffusive SPPs into a collimated beam, whose direction of propagation and beam width can be easily controlled. We also present that a triangular Al2O3 lens significantly reforms the SPPs to a Bessel beam, which possesses non-diffractive and self-healing properties. Our investigation provides unique way to guide the in-plane transport of SPPs by using dielectric subwavelength elements, which may achieve potential applications in plasmonic integrated circuits.

Multimode photon-exciton coupling in an organic-dye-attached photonic quasicrystal.

In this Letter, we present hybrid strong coupling between multiple photonic modes and excitons in an organic-dye-attached photonic quasicrystal. The excitons effectively interact with the photonic modes offered by the photonic quasicrystal, and multiple hybrid polariton bands are demonstrated in both experiments and calculations. Furthermore, by retrieving the measured dispersion map, we get the mixing fractions of photonic modes and excitons, and show that the polariton bands inherit not only the energy dispersion features, but also the damping behaviors from both the photonic modes and the excitons. Our investigation may inspire related studies on multimode light-matter interactions and achieve some potential applications for multimode sensors.

Plasticity of inhibitory processes and associated far-transfer effects in older adults.

Inhibition deficit plays a crucial part in cognitive aging; however, few studies have systematically investigated the plasticity of various inhibitory processes among older adults. We studied the plasticity of 3 inhibitory processes (access, deletion, and restraint) and the extent of far transfer of inhibition training to other general cognitive abilities. Thirty-six participants (aged 60 years and above, M = 70.06, SD = 5.53) were randomly assigned to an adaptive training group that received 12 sessions of training covering 3 inhibitory processes or an active control group that received 4 sessions of mental health lectures. Participants in both groups completed pre- and posttest assessments, in which behavioral and electrophysiological measures were used to evaluate potential transfer effects. Direct training gains were observed for trained tasks of all inhibitory processes, but near-transfer effects were only found within untrained tasks associated with deletion at a composite score level. Furthermore, far-transfer effects were demonstrated for fluid intelligence (Gf) but not for working memory or other general cognitive abilities. Near transfer to deletion and far transfer to Gf persisted at a 3-month follow-up assessment session. We discussed differences in plasticity between the 3 inhibitory processes as well as their possible associations with far transfer to Gf. (PsycINFO Database Record

The roles of different sources of social support on emotional well-being among Chinese elderly.

BACKGROUND: Social support has been widely known as a protective factor for the emotional well-being (EWB) of older adults, but less studies have investigated the roles of different sources of social support (i.e., family and friend support) on different facets of EWB (i.e., positive affect and negative affect) simultaneously. METHODOLOGY AND FINDINGS: In this study, the associations between family/friend support and positive/negative affect were investigated in a sample of 700 Chinese elderly. The EWB and social support were measured with a 12-item affective wordlist (Kahneman et al., 2004) and a self-prepared questionnaire. The results showed that (1) the order of contact frequency and mutual support followed a hierarchical order from spouse, children, to friends; (2) zero-order correlations of both family support and friend support were associated with more positive affect and less negative affect; and when compared with the relative role of family and friend support, (3) spouse (children if spouse is not available) support had greater contribution on decreasing negative affect, while friend support had greater influence on increasing positive affect, even after controlling the demographic, self-rated health and life events variables. CONCLUSION: Family and friend support play different roles on the two facets of EWB of the elderly. These results were better explained in light of the task specificity model rather than the hierarchical compensatory model. Moreover, positive affect may be enhanced by friend support (based on personal interests and selectable) rather than family support (bonded by kinship and not selectable), which added evidences to the socioemotional selectivity theory.

Does co-residence with adult children associate with better psychological well-being among the oldest old in China?

OBJECTIVES: Embedded in a traditional culture where filial piety was honored, living with adult children once had been the most prevalent living arrangement and the best option for Chinese elderly people. This study examined whether co-residence with adult children would be still beneficial to the psychological well-being (PWB) among the oldest old (aged 80 and above) in China today. METHOD: Using data from the fifth wave of the Chinese Longitudinal Healthy Longevity Survey conducted in 2008, the authors examined the living arrangements among the total sample (n = 12,213) and the association between living arrangement and PWB among a subsample (n = 7037) of respondents with normal cognition. RESULTS: (1) More than half (67.1%) of the unmarried oldest old reported being co-resided with their children; while for the married oldest old, the majority of the respondents (62.4%) lived with a spouse only. (2) For the widowed, co-residence with adult children was associated with better PWB compared to living alone; but for the married, co-residence did not bring additional benefits to the PWB. (3) Co-residence of the widowed and children was associated with better life satisfaction compared to living with a spouse only, while it was associated with lower emotional well-being compared to living with a spouse (with or without a child). CONCLUSION: These findings suggest that living arrangements of Chinese oldest old are partially getting westernized, and a majority of them adapt it well. Government programs need to be developed to assist the Chinese oldest old (especially widowed) to live independently.

The roles of working memory updating and processing speed in mediating age-related differences in fluid intelligence.

This study was conducted to investigate the relative roles of working memory updating (updating) and processing speed in mediating age-related differences in fluid intelligence. A sample of 142 normal adults between 18 and 85 years of age performed a set of updating, processing speed, and fluid intelligence tasks. Hierarchical regression analyses indicated that the proportion of unique age-related variance in updating measures was related to the complexity of speed measures. There was a larger proportion of unique age-related variance in updating measures after controlling for the variance in simpler speed measures. Moreover, structural equation modeling showed that updating mediated almost all the age-related effects on fluid intelligence. These results suggest that updating, but not speed, is the critical mediator between age and fluid intelligence. In addition, the speed mediation of age-related differences in fluid intelligence as indicated by previous studies is at least partially derived from the executive component of speed measures.