RESUMO
Polysaccharide of Balanophora involucrata Hook. f. (BPS), the major component of Balanophora involucrata Hook. f., was confirmed the protective effect on liver injury in our previous study. This research aimed to investigate the protective mechanism of BPS on experimental liver injury by attenuating cell ferroptosis through modulating solute carrier family 7 member 11/glutathione peroxidase 4 (SLC7A11/GPX4) pathway. The animal experiment was approved by the Experimental Animal Ethical Committee of Hubei Minzu University and all rats had received human care in compliance with the institutional animal care guidelines. Rats were given intraperitoneal injection of (D-galactosamine, D-GalN) solution (800 mg·kg-1) one time to establish the acute liver injury model. The results showed aspartate amino transferase (AST), alanine aminotransferase (ALT) and 4-hydroxynonenal (4-HNE) levels in serum were decreased, and the contents of reactive oxygen species (ROS), Fe2+, malondialdehyde (MDA) and lipid peroxide (LPO) in liver tissues also decreased and glutathione (GSH) level increased after BPS administration with 200 mg·kg-1. Besides, BPS reduced iron deposition and increased the expression of SLC7A11 and GPX4 proteins in liver tissue. In conclusion, BPS ameliorated experimental liver injury by alleviating cell ferroptosis through SLC7A11/GPX4 pathway. The present study pointed to the possibility of utilizing BPS for protection against liver injury in clinic.
RESUMO
The electronic properties of Cd(1-x)Mn(x)Te/CdTe semiconductor superlattices (SLs) with high Mn concentrations (x up to 0.8) were studied by means of low and room temperature photoluminescence (PL). The samples were grown by MBE on GaAs substrates with CdTe buffers. PL allowed the investigation of the optical emission from the fundamental 11H excitonic transition, revealing the high quantum efficiency and quality of the SLs. The temperature dependence of the excitonic PL energy position and excitonic line-shape broadening were studied. An exciton-longitudinal optical phonon couple model can be used to explain the experimental results very well. Photoreflectance (PR) spectra were also performed in order to compare with the authors' photoluminescence results. The combined use of PL and PR allowed a full understanding of the electronic states and optical emission characteristics of the authors' SLs. The authors' results indicate that high quality Cd(1-x)Mn(x)Te/CdTe SLs with high Mn concentrations can be grown using MBE on GaAs substrates. The possibility to have magnetic semiconductor nanostructures opens the way to applications in the field of spintronics toward devices based on new concepts.
