RESUMO
beta-endorphin-like immunoreactivity (beta-ELI) was measured in cerebrospinal fluid (CSF) of 36 acute head-injured patients and 12 patients without head injury as controls. The mean level of beta-ELI in CSF of controls, mild cerebral contusions, and severe cerebral contusion patients were 51.9 +/- 5.6 pg/ml, 110.5 +/- 14.5 pg/ml, and 173.8 +/- 20.1 pg/ml respectively, with significant difference between them. The results also showed that beta-ELI may reflect the prognosis of acute head-injured patients.
Assuntos
Traumatismos Craniocerebrais/líquido cefalorraquidiano , beta-Endorfina/líquido cefalorraquidiano , Lesões Encefálicas/líquido cefalorraquidiano , Feminino , Humanos , Masculino , Valores de ReferênciaRESUMO
Several dipeptides have been separated into stereoisomers (enantiomers, diastereomers, sequential isomers) by gas chromatography on Chirasil-Val. Sufficiently volatile N-trifluoroacetyl dipeptide methyl esters were formed at ambient temperature, thus avoiding racemization (or epimerization, respectively, and cleavage of the peptide bond. This method is suitable for ascertaining the stereoisomeric composition of dipeptides in biological samples.
