Nonlocal based FISTA network for noninvasive cardiac transmembrane potential imaging.

Objective. The primary aim of our study is to advance our understanding and diagnosis of cardiac diseases. We focus on the reconstruction of myocardial transmembrane potential (TMP) from body surface potential mapping.Approach. We introduce a novel methodology for the reconstruction of the dynamic distribution of TMP. This is achieved through the integration of convolutional neural networks with conventional optimization algorithms. Specifically, we utilize the subject-specific transfer matrix to describe the dynamic changes in TMP distribution and ECG observations at the body surface. To estimate the TMP distribution, we employ LNFISTA-Net, a learnable non-local regularized iterative shrinkage-thresholding network. The coupled estimation processes are iteratively repeated until convergence.Main results. Our experiments demonstrate the capabilities and benefits of this strategy. The results highlight the effectiveness of our approach in accurately estimating the TMP distribution, thereby providing a reliable method for the diagnosis of cardiac diseases.Significance. Our approach demonstrates promising results, highlighting its potential utility for a range of applications in the medical field. By providing a more accurate and dynamic reconstruction of TMP, our methodology could significantly improve the diagnosis and treatment of cardiac diseases, thereby contributing to advancements in healthcare.

Noninvasive Cardiac Transmembrane Potential Imaging via Global Features Based FISTA Network.

Noninvasive electrophysiological imaging plays an important role in the clinical diagnosis and treatment of heart diseases over recent years. Transmembrane potential (TMP) is one of the most important cardiac physiological signals, which can be used to diagnose heart disease such as premature beat and myocardial infarction. Considering the nonlocal self-similarity of TMP distribution and integrating traditional optimization strategy into deep learning, we proposed a novel global features based Fast Iterative Shrinkage/Thresholding network, named as GFISTA-Net. The proposed method has two main advantages over traditional methods, namely, the l1-norm regularization helps to avoid overfitting the model on high-dimensional but small-training data, and facilitates embedded the spatio-temporal correlation of TMP. Experiments demonstrate the power of our method.