Design Optimization and Manufacturing of Bio-fixed tibial implants using 3D printing technology.

To obtain high performance (matching, mechanical properties, and biocompatibility) of personalized biomechanical fixation-type tibial implants, three-dimensional reconstruction was performed using a combination of reverse and positive methods. The implant design was optimized using a topological optimization method, the shape-optimized B-unit structure was filled, and the performance was evaluated for implants prepared by direct forming technology of Selective Laser Melting (3D Printing). The results show obviously reduced weight of the tibial implant, increased stress and displacement, yet with a more uniform distribution. The mechanical properties of the tibial implant were lower than those of the B-units, the weight was lighter, and the stress distribution was more uniform. The surface of the tibial implants prepared by SLM appeared clean and bright, the metal texture was good, the structure between the porous struts was clear, the surface had low powder adhesion, the lap joint was good, and no obvious warping deformation or forming defects were observed. The results of this study provide a foundation for the direct application of high performance personalized biofixation implants.

Effects of Different Processing on the Contents of Paeono1 and Paeoniflolin in Cortex Moutan / 医学研究杂志

Objective A HPLC method was established for the determination of paeonol and paeoniflolin in cortex moutan from different processing.To investigate the necessity of processing to the cortex moutan.Methods The HPLC(high performance liquid chromatogram)method was established for the determination of the contents of the paeonol and paeoniflolin in cortex moutan.The conditions of the chromatograph method was as following:AC18 column was used.The mobile phase for paeonol determination was methanol-water(45:55)and detection wavelength was 274nm.The mobile phase for paeoniflorin determ ination was acetonitrile-0.1%H3PO4(15:85)and detection wavelength was 230nm.Results The results showd that the linear ranges of paeonol and paeoniflorin determ ination were 0.36～2.2?g/L～and 0.042～1.06?g/L respectively.The average recoveries of paeonol and paeoniflorin were 96.30%(RSD=0.97%)and 98.21%(RSD=0.64%)respectively.Conclusion The method is simple,accurate and reproducibility.The experimental results showd that the contents of paeonol and paeoniflorin in coaex moutan from diferent processing were positive correlated,while the contents of cortex moutan from Sichuan were higher than that of the others.We had better combine the pharmacodynamic action study to illuminate the feasibility of processing to the Cortex Moutan.

Quality Standard of Baiban Paste / 中国药房

OBJECTIVE: To establish the quality standard for Baiban paste. METHODS: The two component -Fructus Psoralen and Flos Carthami in Baiban paste were identified by TLC. The contents of Psoralen and Isopsoralen in Baiban paste were determined by HPLC. RESULTS: The TLC spots of both Fructus Psoralen and Flos Carthami were clear with good resolution and free of interference of negative samples. The linear ranges of Psoralen and Isopsorale wre 13.44～67.20 ng and 12.00～60.00 ng, respectively. The average recoveries were 98.86%(RSD=1.09%, n=6) and 98.84%(RSD=1.29%, n=6), respectively. CONCLUSION: The established standard is applicable for the quality control of Baiban paste.

Optimization of Processing Technology of Radix Achyranthis Bidentatae Prepared with Salt through Orthogonal Experiment / 中药新药与临床药理

Objective To optimize the processing technology of Radix Achyranthis Bidentatae prepared with salt. Methods With the amount of the oleanolic acid as the parameter,the processing technology was optimized through orthogonal exper iments design L9(34). Results The optimal processing technology of Radix Achyran this Bidentatae prepared with salt was:the thickness of the medicinal pieces be ing 5～10 mm,baking 20 min with 3.00 %salt at 100 ℃. Conclusion The chosen pr ocessing technology is reasonable.