[The antiviral activity of a number of Soviet chemical preparations and the interferon inducer larifan and their combinations in a model of experimental genital herpes in guinea pigs]. / Protivovirusnaia aktivnost' riada otechestvennykh khimiopreparatov: induktora interferona larifana i ikh komboinatsii na modeli éksperimental'nogo genital'nogo gerpesa morskikh svinok.

Chemical drugs and the Soviet interferon inducer larifan as well as their combinations were evaluated in genital herpes in male guinea pigs. Among the chemical drugs tested, the highest efficacy was observed with 2% phosphonoformic acid trisodiate ointment (its therapeutic effect 62%). The efficacy of 2% cycloguanosine ointment and 0.5% phosphonoacetic ointment did not exceed 43% and 36%, respectively. Topical and systemic use of the interferon inducer larifan produced a marked therapeutic effect (63%). Combined use of purophosphate and cycloguanosine analogues was more effective than the agents alone, yet the effect of the combinations being nothing more than additive.

[Effectiveness of Soviet derivatives of phosphonic acid and their combination with interferon inducers in cell cultures and in a model of herpetic meningoencephalitis in mice]. / Effektivnost' otechestvennykh proizvodnykh fosfonovoi kisloty i ikh sochetanii s induktorami interferona v kul'ture kletok i na modeli gerpeticheskogo meningoéntsefalita myshei.

Nationally synthesized chemopreparations: phosphonoacetic (PAA), phosphonoformic (PFA) acids and acycloguanosine (Acg) exhibit a marked antiherpetic effect in cell cultures and marked protective effect in herpes meningoencephalitis in mice induced by intraperitoneal inoculation of herpes simplex virus type 1 (HSV-1) (43% PFA, 33% PAA, 25% Acg). Both in vitro and in vivo (mouse meningoencephalitis), PFA (its trisodium salt) on the whole proved to be less toxic than PAA but exerted a higher or similar antiherpetic effect. The combined use of pyrophosphate analogues (PAA, PFA) with Acg is more effective that their use separately both in vitro and in herpes meningoencephalitis in mice an produces an additive effect or one similar to it. Systemic inoculation of interferon inducers, lafarine or ridostine, is effective in herpes meningoencephalitis in mice induced by intraperitoneal inoculation of HSV-1 (the protective effect 33% and 26%, respectively). The combined use of ridostine and PAA in herpes meningoencephalitis in mice led to synergistic effect.

[Antiherpetic activity of Soviet-made phosphonic acid derivatives and their combinations with interferon inducers in a model of ophthalmic herpes]. / Protivogerpeticheskaia aktivnost' otechestvennykh proizvodnykh fosfonovoi kisloty i ikh sochetanii s induktorami interferona na modeli oftal'mogerpesa.

A comparative analysis of the effectiveness of national phosphonic acid derivatives (FUK and FMK) and acyclic nucleoside, acycloguanosine (Acg), as well as interferon (INF) inducers, lafarin and ridostin, was carried out on the model of herpetic conjunctivitis in rabbits and guinea pigs. Upon therapeutic-prophylactic administration, lafarin reduced the intensity of eye symptoms 2-fold as compared with the controls (infected but untreated guinea-pigs). In rabbits with herpetic conjunctivitis, the therapeutic schedule of the use of FMK (FUK) and Acg shortened the duration of the disease by 7 and 11 days, respectively, as compared with the control. The combined use of chemical drugs and INF inducers, lafarin or ridostin, reduced the intensity of the disease manifestations 3-fold and shortened the duration of the disease by 8-11 days. The survival rate was 80%-100%. Use of the combination of the two chemical drugs gave an additive effect. The synergistic effect was observed with FMK used in combination with lafarin.