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Bull Exp Biol Med ; 172(5): 552-557, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35348957

RESUMO

Glucose concentration in the saliva is increased in type 1 diabetes mellitus. This parameter directly correlates with markers of the disease in the blood serum. Increased concentration of 8-oxo-2'-deoxyguanosine (8-OHdG) and diene conjugates, markers of oxidative stress, and reduced activities of superoxide dismutase and catalase were also observed in this pathology. Correlation analysis revealed a strong positive correlation between glucose concentration and the levels of oxidative stress markers and a negative correlation between activity of antioxidant enzymes and glucose concentration. The results indicate that the level of 8-OHdG, diene conjugates, and superoxide dismutase and catalase activities can serve as diagnostic markers of pathophysiological changes in the body in type 1 diabetes mellitus.


Assuntos
Antioxidantes , Diabetes Mellitus Tipo 1 , Antioxidantes/metabolismo , Biomarcadores , Catalase/metabolismo , Glutationa Peroxidase/metabolismo , Humanos , Estresse Oxidativo , Saliva/química , Superóxido Dismutase/metabolismo
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