[Immunomodulation in patients with cavernous kidney tuberculosis using piperazine adipinate and amniocene]. / Immunokorrektsiia u bol'nykh kavernoznym tuberkulezom pochek piperazina adipinatom i amniotsenom.

Findings of a complex immunologic examination of 138 patients with active cavernous tuberculosis of the kidneys concurrent with secondary immunodeficiency are presented. Biostimulators and immunomodulating drugs were administered as conservative treatment in this case. Changes in cellular and humoral immunity indices as well as those of the mononuclear-phagocyte system before and after treatment were traced in the groups of patients receiving biogenic stimulators (such, as aloe extract, vitreous body, plasmol, Fibs) and immunoregulating drugs (like piperazine adipinate and injected amniocene). It was found that the biogenic stimulators fail to have a pronounced effect on the immunologic indices. The inclusion of piperazine adipinate and injected amniocene into a complex of antibiotic and chemotherapy brings about a significant improvement of the cellular immunity indices and the mononuclear-phagocyte system function which are inhibited to a greater extent in patients with active destructive nephrophthisis. A recommended use of piperazine adipinate and amniocene as adjuncts to a complex treatment has been proved in patients of this category by means of clinicoimmunologic correlations.

[Effect of polyanions on macrophage-lymphocyte interaction]. / Vlliianie polianionov na vzaimodeistvie makrofagov i limfotsitov.

The effect of polyanions on the interaction of antigen-stimulated macrophages and lymphocytes was studied in vivo. Treatment of cell mixture of macrophages and lymphocytes with poly = A : U or dextran sulfate induced a considerable increase in the number of lymphocytes contacting with macrophages during the first hours of cultivation. Under similar conditions yeast RNA had a certain anticooperative effect. According to the data obtained by scanning electron microscopy, the contacts between the interacting cells were realized by means of cytoplasmic bridges or close membrane connections.

[Effect of a high-polymer, metal-containing biostimulator on the immunological reactivity of the body of experimental animals]. / Vliianie vysokopolimernogo metallsoderzhashchego biostimuliatora na immunolgicheskuiu reaktivnost' organizma éksperimental'nykh zhivotnykh.

"Phodomos", a biostimulator of the "Biomos" group of metal complexes, considerably increases (2-3-fold) antibody production and the phagocytic ability of micro- and macrophages in experimental animals. The preparation has no essential influence on the ability of the bone marrow stem cells for colony formation in the body of irradiated animals.

[Influence of poly-A:U, dextran sulfate and yeast RNA on the colony forming ability of bone marrow in irradiated mice]. / Vliianie poli-A:U, sul'fata dekstrana i drozhzhevoi RNK na kolonieobrazuiushchuiu sposobnost'kostnogo mozga u obluchennykh myshei.

Poly-A:U, dextran sulfate and yeast RNA were shown to increase the number of endogenous (CFU) in sublethally (525 r.) irradiated mouse spleens seemingly as a result of their mutagenic effect on proliferating CFU. The preparations had no effect on the number of exogenous colonies when injected together with bone marrow syngeneic cells transfer from intact donors. Dextran sulfate led to a 2.7 time increase in the number of endogenous colonies in unevenly irradiated mouse spleens mostly due to the CFU migration from the protected sites of the bone marrow. Poly-A:U and yeast RNA complex was ineffective in such an experiment. It is quite possible that the ability of dextran sulfate to increase the migrational potencies of the stem hematogenic cells served as one of the essential factors in the mechanism of its adjuvant activity.