[Immunomorphological changes in the mouse brain after intracerebral administration of a neurotropic strain of influenza virus]. / Immunomorfologicheskie izmeneniia v golovnom mozge myshei pri intratserebral'nom vvedenii neirotropnogo shtamma virusa grippa.

The work dealt with intracerebral inoculation of 150 mice with neurotropic strain of influenza virus A/WSN/33. Virological and immunohistochemical study of virus localization in the mice brain was carried out. It was shown that virus reproduction in ependymal lining cells and plexus choroideus epithelium is followed by destruction of cells and uptake of disintegration products by macrophages. Since the influenza infection is followed by a large number of macrophages involved in gene expression of the main histocompatibility complex, the development of autoimmune reaction with the formation of autoantibodies to brain specific antigens can't be ruled out.