[Endoscopic vacuum therapy in minimally invasive treatment of esophageal perforations]. / Effektivnost' endoskopicheskoi vakuumnoi terapii v kompleksnom minimal'no invazivnom lechenii perforatsii pishchevoda.

OBJECTIVE: To compare the results of endoscopic vacuum therapy (EVT) and open surgery for esophageal perforations. MATERIAL AND METHODS: The study included 60 patients with esophageal perforations between 2010 and 2022. The main group included 29 patients who underwent minimally invasive treatment with EVT, the control group - 31 patients after open surgical interventions. RESULTS: Pneumonia occurred in 21 (72%) and 14 (45%) patients (p=0.04), esophageal stenosis within the perforation zone - in 4 (13.8%) and 1 (3.2%) patient, respectively (p=0.188). Chronic esophageal fistulas were significantly more common in the control group (6 (20.7%) versus 15 (48.4%) patients, p=0.032). The overall duration of treatment (median) among survivors was significantly shorter in the main group: 33 (23; 48) versus 71.5 (59; 93.7) days (p=0.5). However, length of ICU-stay was slightly higher (11 (6; 16) versus 8.5 (5; 12.75) days, p=0.32). Mortality rate was 13.8% (n=4) and 29% (n=9), respectively (p=0.213). Minimally invasive technologies decreased the risk of fatal outcome by 10 times (OR 10.123, 95% CI 1.491-124.97, p=0.035) compared to traditional surgery. CONCLUSION: EVT in complex minimally invasive treatment of patients with mechanical esophageal injuries is an effective method significantly reducing mortality and duration of inpatient treatment compared to traditional surgical approach.

[Surgical treatment of the benign diseases of the esophagus].

Treatment results of 207 patients with the benign diseases of the esophagus, operated on during 2009-2012 yy, were analyzed. The diseases included the burn stricture of esophagus, cardiospasm, esophageal achalasia, hiatal hernias and diverticles. Indications to different treatment algorithms were substantiated. Postoperative complications were registered in 22 (10.6%) patients; the postoperative lethality was 1.6%. The authors concluded the high efficacy of the used methods of treatment.

[The use of Octreotide-depo for the pancreatitis' prophylaxis after radical surgery of gastric cancer with lymphadenectomy].

The efficacy of the medicamentous prophylaxis of the acute postoperative pancreatitis (APP) was estimated in 594 patients. They all were divided into 3 groups: 1st was treated with octreotide, 2nd - with octreotide-depo, 3rd - with 5-ftoruracil and dalargin. Patients of the 3rd group showed the highest levels of α-amylase in both blood and drainage fluid during the early postoperative period. The frequency and severity of postoperative complication rates were the lowest in those patients, who received octreotide-depo and was 3,06%; whereas among patients of the 2nd group it was 16,8% and among those, who were treated with 5-ftoruracil and dalargin, it was 22,4%. The destructive forms of pancreatitis were registered in 2nd and 3rd groups in 1 and 3 patients, respectively. Intraabdominal abscesses were registered in 1 patient of the 1st and 6 patients of the 3rd group, respectively. The lethality rate was 0.9% in the 1st group; 1.02% in the 2nd and 1.8% in the 3rd group. The use of somatostatine analogues in the prophylaxis of postoperative complications proved to decrease overall complications' rate and, first of all, the rate of postoperative destructive pancreatitis. The use of the prolonged forms of somatostatine analogues, i.e., octreotide depo 10 mg is considered to be highly effective.

[Central hemodynamics under conditions of combined anesthesia on the basis of a thoracic epidural block].

The authors set themselves a task of assessing systemic hemodynamic parameters under combined general anesthesia on the basis of a thoracic epidural block (TEB) versus combined general anesthesia during thoracoabdominal interventions. Thirty patients were examined. Their physical status was in ASA Class II-IV. The preoperative examination was as follows: electrocardiography (ECG) (at rest), ECG (during exercise), and 24-hour ECG monitoring. Hemodynamic parameters, such as systolic blood pressure (BP), diastolic BP, mean BP, and heart rate), were intraoperatively measured by invasive and noninvasive techniques. By using the measurements of cardiac output (extrasternal Doppler study), the authors calculated cardiac index, specific peripheral vascular resistance (SPVS), and stroke index (SI). They made 24-hour ECG monitoring intra- and postoperatively (on days 1 and 5, respectively). The findings suggest that inclusion of TEB in a complex of anesthetic maintenance of thoracoabdominal operations along with combined or total intravenous anesthesia shows better hemodynamic changes, as indicated by a 31% increase in SI and a 32.6% decrease in double product with the stable values of mean BP and heart rate, which was not noted in the control group. The dose of narcotic analgesics was decreased by 2.6 times.

[Early cancer of stomach].

Results of surgical treatment of 170 patients with early cancer of the stomach are analyzed. There were 113 patients with tumor invasion within the bounds of the mucous membrane (m -- 113), the others had invasion within the bounds of the submucous membrane (sm -- 57 patients). Impressed and ulcered macroscopic types of early cancer (IIc + III) were diagnosed most often: 57% m+sm (97 of 170), 58.4% m+sm (97 of 170), 54.4% sm (31 of 57), respectively. Poorly differentiated tumors prevailed over moderate- and well-differentiated tumors - 68.8% (117 of 170) and 31.2 (53 of 170) patients, respectively. Subtotal distal resection of the stomach has been performed in 118 (69,4%) patients, subtotal proximal resection -- in 13 (7.7%), gastrectomy -- in 22 (12.9%), resection of 2/3 stomach -- in 14 (8.2%), resection of the cardia - in 3 (1,8%). Lymphadenectomy has been performed in 156 patients including 1 (0.6%) patient with D0-lymphadenectomy, 88 (56.4%) - D1, 62 (39.7%) -- D2, and 5 (3.2%) -- D3. Metastases to the regional lymph nodes have been revealed in 8 (5%) cases -- 2 m and 6 sm. Extended lymphodissections (D2 and D3) have improved significantly long-term results. Five-year survival among the patients who had undergone extended operations with D2 and D3 lymphadenectomies was higher compared with patients after limited and standard operations (D0 and D1) -- 96.0+/-2.5 and 87.0+/-3.5%, respectively.

[Completion of esophagoplasty by means of transplant's remobilization].

Experience in completion of esophagoplasty by means of old transplant's remobilization in 54 patients is analyzed. Primary esophagoplasty in 52 patients was performed for burn stricture, 1 -- for traumatic stricture, 1 -- cancer of the esophagus. In 26 patients the cause of incomplete esophagoplasty was deficient length, in 11 -- necrosis, in 8 -- doubtful viability of transplant, in 7 -- insufficiency of esophageal anastomosis, in 2 -- prolonged obliteration of it. Total remobilization was performed in 41 patients, partial -- in 13. Thirty-six colic, 17 intestinal and 1 gastric transplants were used repeatedly. Esophagoplasty was completed in 50 patients, in 42 of them by one stage. In the rest 4 patients delayed pharyngoplasty was performed in the ENT clinic. One (1.8%) patient died in hospital due to insufficiency of proximal anastomosis and phlegmon of the thorax. Long-term result was studied in 40 patients: it was good in 25 patients, satisfactory -- in 12, bad -- in 3 patients.

[Experience in repeated esophagoplasty].

Experience in repeated esophagoplasty in 58 patients is analyzed. Fifty-four patients of them had reoperation because of incomplete plastic reconstruction, 4 patients -- because of artificial esophagus (cancer, papillomatosis, trauma) diseases. Primary esophagoplasty in 47 patients was performed due to burn stricture of the esophagus, in 9 -- due to cancer of the cardia and esophagus, in 1 -- due to peptic stricture, and in 1 -- due to leiomyoma of the esophagus. The causes of unsuccessful esophagoplasty were the following: necrosis of the transplant (28 patients), extensive obliteration of cervical anastomosis (6), insufficiency of intrapleural anastomosis (4), initially short length of the transplant (4), doubtful vitality of the transplant (1 patient). Subtotal repeated reconstruction of the esophagus was performed in 34 patients, total -- in 21, segmental (with a fragment of the intestine on a long vascular pedicle) -- in 3 patients. Left half of the colon was used as new material in 38 patients, small intestine -- in 12, ileocolon -- in 4, stomach -- in 3 patients. Repeated restrosternal esophagoplasty with left half of the colon was performed most often (27 patients). Reconstruction was completed in 55 patients. Complications were seen in 19 patients. There were no cases of hospital lethality. Long-term results were followed up in 49 patients, stricture of cervical anastomosis has diagnosed in 17 of them. Result of repeated esophagoplasty was good in 26 patients, satisfactory -- in 19, poor -- in 4 patients.

[Treatment of a burn stricture of the esophagus complicated with a fistula].

The experience in the treatment of esophageal fistulas is analyzed. Necessity and expediency of bougienage of esophageal burn stricture in patients with fistulas are discussed, indications and contraindications to bougienage of esophageal stricture complicated with a fistula are formulated. Surgical treatment of these patients (disfunction of esophageal fistulas and different variants of esophagoplasty) are considered.

[Radical surgical treatment of early cancer of the stomach]. / Radikal'noe khirurgicheskoe lechenie rannego raka zheludka.

Results of radical surgical treatment of 86 patients with early cancer of the stomach are analyzed. Among revealed macroscopic types of early cancer of the stomach (B0), type I (elevated) was seen in 26 (31%) patients, type IIa (superficial raised) - in 8 (9%), type IIb (superficial plane) - in 7 (8%), type IIc (superficial excavated) - in 20 (23%), type III (ulcerated) - in 25 (29%) patients. Adenocarcinoma was the prevalent tumor - 84 (98%) patients, in 1 (1%) case undifferentiated cancer was revealed and in 1 (1%) - carcinoid tumor. Tumor invasion was limited by mucosa in 49 (57%) patients, in submucosa - in 37 (43%). Metastases to lymph nodes were diagnosed in 4 (5%) patients. Subtotal proximal resection performed in 6 patients, subtotal distal resection - in 60, gastrectomy - in 20 patients. Lymphadenectomy corresponded to D1 in 30 cases, to D2 - in 51, to D3 - in 5 cases. Complications after surgery were seen in 21 (24%) patients. Cancer in the gastric stump was diagnosed in 3 (4%) patients 2, 4 and 6 years after primary subtotal distal resection of the stomach with D1 lymphadenectomy. All these patients underwent extirpation of gastric stump. Radical surgery for early cancer of the stomach must include extended lymphadenectomy D2 or more.

[Esophagoplasty with the colon in flap patients with burn strictures of the esophagus]. / Plastika pishchevoda tolstoi kishkoi u bol'nykh s ozhogovymi strikturami pishchevoda.

Results of coloesophagoplasty in 366 patients with long burn strictures of the esophagus are presented. The lesion was total in 74 (21.2%) of them. Inefficacy of bougieurage was indication for plastic surgery in 133 (36.3%) patients, complete obliteration of esophagus--in 53 (14.5%). Left half of the colon was used in 296 (80.9%) cases, transverse colon--in 48 (13.1%), right half of the colon--in 22 (6.0%) cases. Retrosternal shunting esophagoplasty was performed in 247 (67.5%) patients. Complications were in 84 (34.0%), necrosis of the transplant--in 4 (1.6%) patients. Extirpation of the esophagus with posteriormediastinoplasty was performed in 16 (4.4%) patients, in 14 of them--transhiatally. Complications occurred in 7 patients coloesophagopharyngoplasty was carried out in 52 (14.2%) patients with combined stricture of the esophagus and the pharynx, in 23 of them--simultaneously. Complications were in 28 (53.8%) patients. Intrapleural of coloesophagoplasty was performed in 51 patients. General hospital lethality was 3.3%. Long-term results were studied in 259 patients. Good results of esophagoplasty were seen in 135 (52.1%) patients, satisfactory--in 65 (25.1%), unsatisfactory--in 59 (22.8%) patients. Dysfunction of the artificial esophagus was seen in 22.0% patients, 12.7% patients underwent repeated reconstructive surgeries.

[One-stage esophagoplasty with pathologically changed or operated stomach in patients with benign esophageal strictures]. / Odnomomentnaia ézofagoplastika patologicheski izmenennym ili operirovannym zheludkom u bol'nykh s dobrokachestvennymi strikturami pishchevoda.

Results of surgical treatment of 71 patients who have undergone extirpation of the esophagus with one-stage plastic surgery with pathologically changed or operated stomach are presented. All the patients suffered from benign diseases of the esophagus: burn and peptic strictures, peptic esophageal ulcers, cardiospasm of degree IV, benign tumors. Fifty-one patients had been previously operated on the stomach, 10 patients had burn deformation of the stomach, 3--benign tumors of the esophagus involving the stomach, the others--gastric and/or duodenal ulcers. In all the cases an isoperistaltic gastric tube was used for plastic repair of the esophagus. Postoperative lethality was 1.4%.

[Local esophagoplasty in patients with burn strictures of the esophagus]. / Mestnaia ézopfagoplastika u bol'nykh s ozhogovymi strikturami pishchevoda.

Local plastic reconstruction of short burn strictures of the esophagus (SBSE) was performed in 14 patients aged from 22 to 37 years, 9 were men, 5--women. Decreased body mass was revealed in all the patients, mass deficit over 20% was in 4 (28.6%) of them. SBSE located in the upper third of the esophagus in 9 (64.3%) patients, in middle third--in 5 (35.7%). Local esophagoplasty was performed from cervical approach in 9 (64.3%) patients, from right-sided thoracotomy--in 5 (35.7%). Dissection of SBSE with 3/4 anastomosis was performed in 5 (35.7%) patients; circulatory resection of esophageal stricture with end-to-end anastomosis--in 7 (50.0%); detour side-to-side anastomosis without stricture resection--in 2 (14.3%). There was no hospital lethality. Postoperative complications were seen in 14.2% cases. Long-term results were good in 10 (71.4%) patients, satisfactory (strictures of anastomosis)--in 3 (21.4%), unsatisfactory--in 1 (7.2%). Local esophagoplasty is indicated for patients with SBSE when bouginage and dilatation of stenosis are not effective.

[Surgical policy for patients with prolonged esophageal burn strictures]. / Lechebnaia taktika i vybor khirurgicheskogo lecheniia bol'nykh s protiazhennymi ozhogovymi strikturami pishchevoda.

Concept of early radical surgical treatment of prolonged esophageal burn strictures (PEBS) is presented. From 1980 to 2000 one-stage esophagoplasty was performed in 503 (62.0%) of 811 patients with PEBS. Bouginage was effective in 17.2% patients. Extirpation of the esophagus with posteriormediastinal plastic repair was performed in 119 patients. Mean age of patients was 48 years, mean anamnesis time--11 years. 13 (10.9%) patients had total PEBS. Combined burn of the stomach was revealed in 25 (21.0%), of the pharynx--in 4 (3.4%) patients. Isoperistaltic gastric tube was used in 102 (85.7%) patients, whole stomach--in 1 (0.8%), left half of the large intestine (antiperistaltic)--in 16 (13.4%) patients. Esophagectomy was performed transiatally in 114 (95.8%), from three approaches (+ right-sided thoracotomy)--in 5 (4.2%) patients. Transplant on the neck was connected with esophagus in 106 (89.1%) patients, with the pharynx--in 13 (10.9%). Combined operations were performed in 14 (11.8%) patients. Intraoperative complications were in 6 (5.0%), postoperative--in 39 (33.0%) patients. Insufficiency of cervical anastomosis was seen in 16 (13.4%), paresis of recurrent nerve--in 4 (3.4%) patients. Hospital lethality was 3.4% (4 patients). Good and satisfactory long-term results of esophagoplasty were achieved in 97 (97.0%) patients. PEBS is the indication for transhiatal extirpation of the esophagus with its one-stage plastic repair with gastric tube (or large intestine) during first 6 months after burn.