RESUMO
Experience of diagnosis and treatment of primarily-multiple gastric cancer, combined with malignant colonic tumors in 27 patients was summarized. One-stage combined radical treatment of the patients is the most effective one.
Assuntos
Neoplasias do Colo/patologia , Neoplasias do Colo/terapia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Primárias Múltiplas/terapia , Neoplasias Gástricas/patologia , Neoplasias Gástricas/terapia , Adulto , Terapia Combinada , Feminino , Humanos , Masculino , Estudos RetrospectivosAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Linfoma não Hodgkin/radioterapia , Antibióticos Antineoplásicos/administração & dosagem , Antibióticos Antineoplásicos/uso terapêutico , Antineoplásicos Alquilantes/administração & dosagem , Antineoplásicos Alquilantes/uso terapêutico , Antineoplásicos Hormonais/administração & dosagem , Antineoplásicos Hormonais/uso terapêutico , Antineoplásicos Fitogênicos/administração & dosagem , Antineoplásicos Fitogênicos/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Clorambucila/administração & dosagem , Clorambucila/uso terapêutico , Terapia Combinada , Ciclofosfamida/administração & dosagem , Ciclofosfamida/uso terapêutico , Doxorrubicina/administração & dosagem , Doxorrubicina/uso terapêutico , Humanos , Linfoma não Hodgkin/tratamento farmacológico , Prednisolona/administração & dosagem , Prednisolona/uso terapêutico , Teleterapia por Radioisótopo , Dosagem Radioterapêutica , Fatores de Tempo , Vincristina/administração & dosagem , Vincristina/uso terapêuticoRESUMO
Preoperative intraarterial chemotherapy was administered to 69 patients with gastric cancer. In 34 patients the tumor was localized in the antral portion, in 27 in the body of the stomach involving the proximal portion, and in 8 total involvement of the stomach was revealed. Left gastric artery was catheterized in 42 patients, right gastric-omental artery in 27. An original method of "loop" catheterization of celiac artery branches was used permitting a selective probing of gastric arteries proper. For prolonged intraarterial chemotherapy of gastric cancer adriablastin or farmorubicin were used in single dose 30 mg/M2, 5-fluorouracil in dose 500 mg/M2; the cytostatics were infused in 2-3 sessions. Immediate results of intraarterial chemotherapy were assessed by angiography and other instrumental methods of investigation, as well as intraoperatively and by morphometric analysis. In 62.4% of patients significant or total destruction of the tumor was attained, the volumic share of a viable tumor component being 0 to 2.1%. Altogether 95% of patients survived the follow-up of 2 to 30 months.
Assuntos
Adenocarcinoma/tratamento farmacológico , Carcinoma de Células Escamosas/tratamento farmacológico , Infusões Intra-Arteriais , Neoplasias Gástricas/tratamento farmacológico , Adenocarcinoma/mortalidade , Adenocarcinoma/cirurgia , Adulto , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/cirurgia , Terapia Combinada , Doxorrubicina/administração & dosagem , Epirubicina/administração & dosagem , Feminino , Fluoruracila/administração & dosagem , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Cuidados Pré-Operatórios , Neoplasias Gástricas/mortalidade , Neoplasias Gástricas/cirurgia , Fatores de TempoRESUMO
Anticancer prophylactic and treatment measures are approved initially among small populations contingents and, hence, their results are not essentially effecting demographic values. Changes of the state of selected contingents are evaluated by means of lethality or survival values. On the example of gastric cancer patients survival, the authors determine the period of observation necessary for preliminary evaluation of the efficiency of anticancer measures. During 5 years there was no clear change of survival of patients with gastric cancer of stage I-II (P > 0.05). The duration of the period of statistically valid reduction (P < 0.001) of the survival of patients with gastric cancer (stage III-IV) was two years. Thus, changes of the level of two year survival in patients advanced gastric cancer under the effect of anticancer measures may be used for express-evaluation of these measures.
Assuntos
Neoplasias Gástricas/prevenção & controle , Feminino , Humanos , Masculino , Estadiamento de Neoplasias , Avaliação de Programas e Projetos de Saúde , Estudos Retrospectivos , Fatores Sexuais , Neoplasias Gástricas/mortalidade , Neoplasias Gástricas/patologia , Ucrânia/epidemiologiaRESUMO
A radioimmunological analysis of the changes in concentration of tumour markers CA 19-9, REA, beta 2-microglobulin, trypsin and C-peptide was carried out in 53 patients with pancreatic cancer and in 14 patients with cancer of the major duodenal papilla before and 7-10 days after the treatment. A control group was comprised of 116 volunteers. The levels of the tumour markers decreased after the combined use of remote radiotherapy and pancreaticoduodenal resection (PDR). After creation of cholecysto-enteroanastomosis and performance of radiotherapy they remained without changes. Exocrine pancreatic function after remote radiotherapy, especially in combination with PDR, was sharply suppressed.
Assuntos
Ampola Hepatopancreática , Biomarcadores Tumorais/análise , Peptídeo C/análise , Neoplasias do Ducto Colédoco/metabolismo , Neoplasias Pancreáticas/metabolismo , Tripsina/análise , Antígeno CA-19-9/análise , Terapia Combinada , Neoplasias do Ducto Colédoco/terapia , Humanos , Antígenos CD15/análise , Neoplasias Pancreáticas/terapia , Proibitinas , Radioimunoensaio , Procedimentos Cirúrgicos Operatórios/métodos , Fatores de Tempo , Resultado do Tratamento , Microglobulina beta-2/análiseRESUMO
To reduce the risk of intraoperative metastases and increasing ablastic principles in radical surgical treatment of patients with cancer of the rectum the authors developed a scheme of preoperative treatment including endolymphatic polychemotherapy and UHF-hyperthermia. 5-fluorouracil and platidiam were used in the treatment of 30 patients with different histological types of adenocarcinomas of the rectum (grade III-IV). After treatment the viable epithelial component in the tumour was 26.5% as compared with 44.8% in the control. The effect of treatment was favourable both objectively and subjectively. The treatment was well tolerated.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Hipertermia Induzida , Micro-Ondas , Neoplasias Retais/terapia , Adulto , Idoso , Terapia Combinada , Anastomose Endolinfática , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Retais/cirurgiaRESUMO
Ceruloplasmin as a modulator was used for the first time in the clinical practice in 30 patients with gastric cancer in the course of postoperative intraabdominal adjuvant chemotherapy. It was established that ceruloplasmin was well tolerated by the patients and its use during polychemotherapy is accompanied by normalization of the levels of natural ceruloplasmin and iron in the blood serum that are usually reduced in patients with gastric cancer, reduces activation of lipid peroxidation and improves the course of postoperative period. Ceruloplasmin possesses a week immunomodulating action in polychemotherapy which is expressed in the increase of the percentage content of T-lymphocytes. Use of ceruloplasmin tended to improve the functional state of the cardiovascular system.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ceruloplasmina/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Adjuvantes Imunológicos , Formação de Anticorpos/efeitos dos fármacos , Ceruloplasmina/efeitos adversos , Ceruloplasmina/análise , Doxorrubicina/administração & dosagem , Doxorrubicina/efeitos adversos , Avaliação de Medicamentos , Fluoruracila/administração & dosagem , Fluoruracila/efeitos adversos , Coração/efeitos dos fármacos , Humanos , Imunidade Celular/efeitos dos fármacos , Ferro/sangue , Peroxidação de Lipídeos/efeitos dos fármacos , Cuidados Pós-Operatórios , Neoplasias Gástricas/sangue , Neoplasias Gástricas/imunologiaRESUMO
The study including 414 patients aged over 60 years suffering lung esophageal, gastric and colorectal cancer was carried out to assess the possibility of preventing postoperative complications. Preoperative preparation, anesthesiologic medication and drug treatment in the early postoperative period included vitamins, eleutherococcus, sodium oxybutyrate, retabolil, splenin, curantyl, heparin, panangin, sulfalen and trichopol. In that group, the overall postoperative complication rate was 1.5 times lower and that of purulent complications, cardiovascular disorders, pneumonia and pancreatitis--2 times lower than those in 642 controls. The duration of postoperative stay in the hospital was shorter and the postoperative lethality tended to decrease. Topical treatment with methylsiloxane-immobilized gentamycin and 5-fluorouracil was shown to prevent development of purulent complications and pancreatitis.
Assuntos
Neoplasias Esofágicas/cirurgia , Neoplasias Gastrointestinais/cirurgia , Neoplasias Pulmonares/cirurgia , Complicações Pós-Operatórias/prevenção & controle , Idoso , Neoplasias Esofágicas/epidemiologia , Feminino , Neoplasias Gastrointestinais/epidemiologia , Humanos , Neoplasias Pulmonares/epidemiologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Ucrânia/epidemiologiaRESUMO
The authors analyze results of combined treatment of 72 patients using preoperative intensive gamma teletherapy. Increase of 4-year survival was observed only in patients showing no regional metastases and equalled 18.7%. The authors worked out a method of preoperative radiation treatment against the background of induction of endogenous interferon by curantyl. The course of radiation therapy was carried out in association with a 2-3 times increase of the interferon levels in the blood and was accompanied by a reduction of the immunodepressive effect of gamma teletherapy on the body.
Assuntos
Cuidados Críticos/métodos , Indutores de Interferon/uso terapêutico , Cuidados Pré-Operatórios/métodos , Teleterapia por Radioisótopo , Neoplasias Gástricas/terapia , Terapia Combinada/métodos , Dipiridamol/uso terapêutico , Raios gama/uso terapêutico , Humanos , Neoplasias Gástricas/imunologia , Neoplasias Gástricas/mortalidadeAssuntos
Neoplasias Duodenais/patologia , Duodeno/patologia , Neoplasias Pancreáticas/secundário , Adulto , Neoplasias Duodenais/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias Pancreáticas/etiologia , Neoplasias Pancreáticas/cirurgia , Fatores de TempoRESUMO
Experience with 62 combined operations on patients with nonorganic new growths of the true pelvis is discussed. They accounted for 33.3% of 227 radical interventions undertaken for this disease. The ages of the patients ranged from 4 months to 64 years. Ten patients were admitted after exploratory laparotomies. Benign new growths were diagnosed in 14 and malignant new growths in 48 patients. Different variants of operative approaches were used. Most frequently the tumor was resected together with bones, iliac vessels, genitalia, and urinary bladder. Various complications were noted in 39 patients who were operated on. Hemorrhage was the most frequent and menacing complication--in 26 patients. Two patients died. Recurrences were found in 8 of a group of 60 patients discharge from the clinic. After combined operations for malignant nonorganic tumors of the true pelvis 3-year survival was 36.0%, 5-year survival was 29.4%.
Assuntos
Exenteração Pélvica/métodos , Neoplasias Pélvicas/cirurgia , Neoplasias Retroperitoneais/cirurgia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Estadiamento de Neoplasias , Neoplasias Pélvicas/mortalidade , Neoplasias Pélvicas/patologia , Prognóstico , Neoplasias Retroperitoneais/mortalidade , Neoplasias Retroperitoneais/patologiaRESUMO
In patients with gastric cancer, depending on location of a tumor, the left gastric or right gastroepiploic artery was catheterized via a puncture of the femoral artery, the course of polychemotherapy with fluorouracil and adriablastin was carried out, then the operative treatment was performed. In 62.4% of the patients, the complete, in 18.8%--the partial destruction of a tumor was achieved, in 18.8%, the effect was insignificant.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Neoplasias Gástricas/tratamento farmacológico , Adulto , Doxorrubicina/administração & dosagem , Estudos de Avaliação como Assunto , Fluoruracila/administração & dosagem , Humanos , Infusões Intra-Arteriais , Pessoa de Meia-Idade , Cuidados Pré-Operatórios , Neoplasias Gástricas/cirurgia , Fatores de TempoRESUMO
The schemes of postoperative intraperitoneal chemotherapy and polychemotherapy of gastric cancer have been developed. In their use, the 2-year survival of the patients increased by 17.2%, in absence of regional metastases--by 40%, in their presence--by 16.1%, in endophytic growth of tumors--by 14.3%, in exophytic growth--by 11.8% when compared with the results of surgical treatment alone.
Assuntos
Antineoplásicos/administração & dosagem , Neoplasias Gástricas/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Terapia Combinada , Seguimentos , Humanos , Injeções Intraperitoneais , Neoplasias Gástricas/mortalidade , Neoplasias Gástricas/cirurgia , Fatores de TempoRESUMO
Enterosorption as component of preoperative preparation of patients with cancer-induced mechanical jaundice assured subsidence of intoxication, improvement in hepatic and renal functions, better postoperative course, lower rates of purulent and other postoperative complications and lower postoperative lethality.
Assuntos
Neoplasias do Sistema Biliar/terapia , Colestase/terapia , Absorção Intestinal , Neoplasias Pancreáticas/terapia , Complicações Pós-Operatórias/prevenção & controle , Cuidados Pré-Operatórios/métodos , Adsorção , Neoplasias do Sistema Biliar/sangue , Neoplasias do Sistema Biliar/complicações , Bilirrubina/sangue , Colestase/sangue , Colestase/etiologia , Terapia Combinada , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/sangue , Neoplasias Pancreáticas/complicações , Complicações Pós-Operatórias/sangueAssuntos
Neoplasias Gástricas/terapia , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Transfusão de Sangue , Terapia Combinada , Ciclofosfamida/administração & dosagem , Fluoruracila/administração & dosagem , Humanos , Imunoterapia Ativa , Masculino , Pessoa de Meia-Idade , Indução de Remissão , Fatores de TempoRESUMO
The authors had 170 patients with retroperitoneal nonorganic tumors under observation. Operations were conducted on 143 patients. Patients with malignant tumors received intensive radiotherapy in a dose of 5Gr every other day to a total dose of 20-30 Gr. A course of telegammatherapy was applied in 17 patients in the preoperative period; in 22 patients the seat of the removed tumor was treated by telegammatherapy after radical operation. In 25 patients telegammatherapy was conducted as an independent method of treatment in inoperable cases and after exploratory laparotomy. Operative treatment of patients with benign tumors produced the best late-term results. Among patients treated for malignant new growths the late-term results were best when the seat of the removed tumor was exposed to intensive radiotherapy.
Assuntos
Neoplasias Retroperitoneais/terapia , Adolescente , Adulto , Idoso , Terapia Combinada , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Teleterapia por Radioisótopo , Dosagem Radioterapêutica , Neoplasias Retroperitoneais/radioterapia , Neoplasias Retroperitoneais/cirurgia , Fatores de TempoRESUMO
Results are analyzed of the treatment of 520 patients with diffuse gastric cancer using different schemes that included chemotherapy with fluorouracil, intraabdominal polychemotherapy with fluorouracil and adriablastin, immunotherapy with yeast polysaccharides and thymus hormone--taktivin. Chemotherapy supplemented by immunotherapy essentially increases survival. Intraabdominal administration of antitumour drugs in gastric cancer is anatomically more adequate than the intravenous route.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Adjuvantes Imunológicos/administração & dosagem , Terapia Combinada/métodos , Doxorrubicina/administração & dosagem , Fluoruracila/administração & dosagem , Humanos , Imunoterapia/métodos , Metástase Linfática , Estadiamento de Neoplasias , Peptídeos/administração & dosagem , Neoplasias Gástricas/mortalidade , Neoplasias Gástricas/patologia , Extratos do Timo/administração & dosagem , Zimosan/administração & dosagemRESUMO
Medical aid for patients with carcinoma of the stomach is rendered much more effectively in specialized oncological institutions than in general hospitals. Removal of the shortcomings of primary treatment may be an important measure in preventing a recurrence of the disease. Patients with carcinoma of the stomach of clinical group III must undergo complex dynamic examination and treatment according to indications. The choice of the method for treatment of recurrent gastric carcinoma must be strictly individualized, which makes it possible to achieve good immediate and late results in the management of this category of patients.