[The granulocyte-macrophage colony stimulating factor and the radiation protective effect of yeast mannan]. / Stimuliruiushchii granulotsitarno-makrofagal'nyi rostok i radiozashchitnyi éffekty drozhzhevogo mannana.

The effect of mannan polysaccharide on the haemopoiesis recovery in irradiated mice has been investigated. Mannan has been shown to exert both the protective and the stimulatory effect: it accelerates restoration of femur bone marrow cellularity and nucleate cell number in the peripheral blood and causes a larger initial yield and subsequent more rapid postirradiation dynamics of pluripotent haemopoietic stem cells and precursor cells of granulocytes and macrophages.

[Effect of anabol on the functional activity indices of mononuclear phagocytes]. / Vliianie anabola na nekotorye pokazateli funktsional'noi aktivnosti mononuklearnykh fagotsitov.

Anabol is a biopolymer from the complex of components extracted from the surface layer of the Lactobacillus bulgaricus cell wall. Its effect on certain indices of the functional activity of mononuclear phagocytes was studied. Administration of the preparation in a dose of 20 mg/kg 24 hours before the investigation resulted in lowering of the stain half-life in the general blood flow and increasing of the fibronectin levels in blood plasma of rats. Activation of the metabolic activity estimated by nitroblue tetrazolium test as well as resident cells and induced macrophages was observed. 24 hours after the anabol administration there was noted a marked increase in the pool of the precursors of granulocytes and macrophages, the stimulating effect being preserved for up to 3 days. The results showed that anabol had an effect on various elements of the system of mononuclear phagocytes. It may be useful in complex therapy aimed at increasing the host resistance to diverse toxic substances and bacterial infection.

[Effect of anabol on the functional activity indices of mononuclear phagocytes]. / Vliianie anabola na nekotorye pokazateli funktsional'noi aktivnosti mononuklearnykh fagotsitov.

In this investigation the influence of anabol, a biopolymer preparation incorporated into a complex of extracted components obtained from the surface layer of Lactobacillus bulgaricus cell wall, on some functional activity characteristics of mononuclear phagocytes has been studied. The injection of the preparation in a dose of 20 mg/kg of body weight 24 hours prior to the experiment leads to a decrease in the time necessary for the elimination of one-half of the total amount of ink from the blood stream and to an increase in the content of fibronectin in the blood plasma of rats. The activation of the metabolic activity of resident and induced macrophages, evaluated by the nitro blue tetrazolium reduction test, is observed. On the next day after the injection of anabol the sharp increase of the pool of granulocyte and microphage precursors is observed; the stimulating effect may be retained as long as 3 days. The results thus obtained indicate that anabol acts on different elements of the system of mononuclear phagocytes and can be effective in the complex therapy aimed at the increase of the body resistance to any toxic substances and bacterial infection.

[Effect of radiation, thermal or combined radiation-thermal damage to a population of progenitor cells of the granulocyte-macrophage series in mouse bone marrow]. / Vliianie radiatsionnogo, termicheskogo ili kombinirovannogo radiatsionno-termicheskogo porazheniia na populiatsiiu kletok-predshestvennikov granulotsitarno-makrofagal'nogo riada v kostnom mozge myshei.

The recovery of a population of granulopoietic-monocytic colony-forming units of mouse bone marrow was only slightly inhibited during the first two weeks after exposure to a mixture of radiation (4 Gy) and heat (burn of 10 per cent of the skin). In the interval between days 14 and 28 following the effect, their number reached the control level, then it decreased again.

[Role of the temperature factor in determining the nature of the chronotropic response of the heart of cats in the simulation of increased venous inflow]. / Rol' temperaturnogo faktora v opredelenii kharaktera khronotropnogo otveta serdtsa koshek pri imitatsii uvelicheniia venoznogo pritoka.

The heart rate changes in response to the imitation of venous input to the heart by infusion of an additional blood volume to the right atria have been studied on anesthetized by chloralose cats. It has been discovered that patterns of the heart rate changes are determined by the infused blood temperature if it is equal to the blood temperature in heart, tachycardia appears, if it is below this temperature, bradycardia develops. These data explain, from our point of view, the contradictory results obtaining by different authors in experiments with the imitation of the increased venous input (Bainbridge reflex).