RESUMO
Skin melanoma is believed to result from malignization of an inborn or acquired pigmented nevus under the action of a number of causative agents. With regard to this, the comparative analysis of skin melanoma tissue samples taken from patients of both sexes and pigmented nevus tissue samples was performed by polarization fluoroimmunoassay. The study involved analyzing the activity of plasmin, plasminogen, concentration and activity of urokinase type plasminogen activator, tissue type plasminogen activator, plasminogen activator inhibitor, as well as the level of growth factors--vasculoendothelial one and its receptor, epidermal one and its receptor, transforming one, fibroblasts growth factor, insulin-like 1 and 2 growth factors. The detected changes indicate possible mechanisms of malignant transformation of skin nevi. The obtained results can be used for developing the risk evaluation methods for neoplastic transformation of nevi as well as prevention methods.
