RESUMO
Changes in lymphocyte and monocyte counts in peripheral blood of patients who had undergone combined treatment for malignant cutaneous melanoma of low extremities were evaluated. The posttreatment counts were compared with those for mononuclear cell infiltration of tumor stroma. Mononuclear cell levels in blood and in tumor stroma versus patients' survival time were analysed. A moderate correlation between lymphocyte and monocyte (macrophage) levels in tumor stroma, on the one hand, and survival time, on the other, was established.
Assuntos
Melanoma/imunologia , Monócitos/imunologia , Neoplasias Cutâneas/imunologia , Terapia Combinada , Feminino , Humanos , Imunidade Celular , Perna (Membro) , Contagem de Leucócitos , Masculino , Melanoma/patologia , Melanoma/terapia , Estadiamento de Neoplasias , Período Pós-Operatório , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/terapia , Fatores de TempoRESUMO
The lymphatic nodes of intact albino rats were investigated electron microscopically. It was shown that the lymphatic sinuses were restricted by a layer of flattened cells; the basal membrane was absent. Certain distinctions in the structure of the cell lining sinuses and the reticular cells comprising the reticular base of the lymphoid tissue of the lymphatic node were found. The structure of the "sinus network" strands is shown. The structure of the cells of the sinuses lining is shown to be identical to the structure of cells of the vascular endothelium. It suggests the endothelial nature of the lining of the lymphatic node sinuses.