Pictorial Blood Loss Assessment Chart for evaluating heavy menstrual bleeding in Asian women.

INTRODUCTION: Heavy menstrual bleeding is a common gynaecological problem, but some women may prefer not to articulate their menstrual problems. The objective of this study was to evaluate the usefulness and acceptability of the Pictorial Blood Loss Assessment Chart (PBAC) as a selfscreening tool in evaluation of menstrual blood loss among Asian women in Hong Kong. METHODS: This prospective cohort study recruited 206 women from the general gynaecology ward and out-patient clinic: 118 had self-perceived heavy menstrual bleeding and 88 had self-perceived normal menstrual flow. Participants were asked to fill in the PBAC for one menstrual cycle. RESULTS: Compared with women who had self-perceived normal menstrual flow, women with self-perceived heavy menstrual bleeding had significantly higher total PBAC scores and numbers of flooding episodes, larger clot sizes and numbers, more days of bleeding, and lower haemoglobin levels. Receiver-operating characteristic curve analysis demonstrated good pairwise associations of self-perceived symptoms with PBAC score and haemoglobin level. CONCLUSIONS: The PBAC can be used to differentiate self-perceived heavy and normal menstrual bleeding in Asian women in Hong Kong. It can also serve as an additional indicator of possible heavy menstrual bleeding to alert women of the need to seek early medical attention.

Failure of magnesium sulfate infusion to inhibit uterine activity in pregnant sheep.

OBJECTIVES: Our purpose was to determine the effect of magnesium sulfate infusion on nonlabor uterine contractures and corticotropin-induced preterm uterine contractions in pregnant sheep. STUDY DESIGN: Fetal and maternal vascular catheters and uterine electromyographic electrodes were surgically placed in 15 pregnant sheep between 118 and 125 days' gestation. After 3 to 5 days of recovery, magnesium sulfate was infused into 7 ewes with a 0.11 gm/kg bolus over 20 minutes, followed by 0.08 gm/kg/hr. In 8 animals labor was induced with use of an intrafetal corticotropin infusion, after which 4 ewes received magnesium sulfate and 4 received saline solution. Continuous recordings of uterine electromyographic activity, amniotic pressure, fetal heart rate, blood pressure, and tracheal pressure were made. Maternal and fetal magnesium, calcium, albumin concentrations, and blood gases were determined before and during the infusion. RESULTS: Maternal magnesium concentrations increased from an average of 0.94 +/- 0.03 mmol/L to 2.73 +/- 0.1 mmol/L at the end of the bolus, remaining elevated (2.44 +/- 0.17 mmol/L) for 8 hours. Fetal magnesium concentrations (0.89 +/- 0.03 mmol/L before the bolus) did not change with the maternal infusion. In ewes not in labor, uterine contractures occurred 3.7 +/- 0.7 times per 2 hours before and did not change significantly with the infusion of magnesium sulfate. During corticotropin-induced preterm labor uterine contractions were present 13 +/- 3.2 times per hour before infusions and were unchanged by infusion of magnesium sulfate to the ewes. CONCLUSIONS: Magnesium sulfate infusion in pregnant sheep has no effect on either nonlabor uterine contractures or on corticotropin-induced preterm uterine contractions.

Preterm discordant twins: what birth weight difference is significant?

OBJECTIVE: The purpose of this study was to determine the effect of discordant fetal growth on subsequent perinatal and neonatal outcome for different degrees of birth weight discordance in preterm twin gestations. STUDY DESIGN: One hundred twenty-two live born twin sets delivered between 25 and 34 completed weeks' gestation were retrospectively studied. They were stratified into five categories according to the percent difference in infant birth weight: < 10%, 10% to 15%, 15% to 20%, 20% to 30%, and > 30%, which was defined as ([Birth weight of larger twin--Birth weight of smaller twin]/Birth weight of larger twin) x 100. The relationship between different birth weight categories and the perinatal and neonatal outcome and the difference in outcome between the large and small infants within each category were determined. RESULTS: Preterm twin gestations with > 30% birth weight discordance were associated with a higher incidence of infant death (25%), congenital anomalies (37.5%), small-for-gestational-age infants (31.8%), Apgar score < 7 at 5 minutes (33.3%), and periventricular leukomalacia (16.7%), in spite of a higher cesarean delivery rate (79.2%). Outcomes of large and small infants within categories were similar except in the > 30% group, where all deaths occurred in the small infants. CONCLUSION: In preterm twin gestations the use of a 30% birth weight difference to define twin discordance is most clinically relevant in identifying those infants at risk for adverse perinatal outcome.

Waldenström hypergammaglobulinemic purpura and pregnancy.

BACKGROUND: Waldenström hypergammaglobulinemic purpura is characterized by hypergammaglobulinemia, recurring purpura, and an elevated erythrocyte sedimentation rate. It is a rare disease and, to our knowledge, there have been no previous reports of its presence during pregnancy. We report a patient with this disease whose pregnancy was complicated by severe fetal growth restriction (FGR) and acute fetal distress. CASE: A 24-year-old primigravid woman with a history of Waldenström hypergammaglobulinemic purpura and renal insufficiency developed FGR at 32 weeks' gestation. Cesarean delivery was performed at 33.5 weeks because of acute fetal distress, and a 1305-g male infant was delivered. Neonatal outcome was successful. No deterioration of the woman's medical condition occurred during or after her pregnancy. CONCLUSION: Successful pregnancy outcome is possible in women with Waldenström hypergammaglobulinemic purpura. In view of the risk of FGR, close monitoring of fetal growth and well-being is recommended in women with this condition.

Expectant management of preterm prelabour rupture of membranes--the significance of oligohydramnios at presentation.

In a retrospective study, the relationship between oligohydramnios (largest amniotic fluid pocket less than 2 x 2 cm) at the time of presentation and the outcome of expectant management of patients with preterm (< 35 weeks) prelabour rupture of membranes (PROM) was examined in 62 patients admitted with a confirmed diagnosis and in the absence of complications or established labour. There were no differences in the maternal age, incidence of multiparity, or additional complications between patients without (Group 1, n = 24) and with (Group 2, n = 38) oligohydramnios. However in Group 2, 44.7% of the patients developed PROM before 28 weeks and 63.2% were delivered within 48 h of assessment, in contrast to 20.8% (P < 0.05) and 12.5% (P < 0.001), respectively, in Group 1. Group 2 patients had a higher incidence of histological chorioamnionitis (55.3% vs. 29.3%, P < 0.05) and funisitis (44.7% vs. 16.7%, P < 0.02), an earlier mean gestation at delivery (29.1 +/- 2.8 weeks vs. 31.5 +/- 2.0 weeks, P < 0.001) and lower birth weight (1373 +/- 467 g vs. 1856 +/- 496 g, P < 0.001). Our results indicate that oligohydramnios at presentation of preterm PROM is an unfavourable prognostic sign in the expectant management of these pregnancies.