Differential decay of gist and detail memory in older adults with amnestic mild cognitive impairment.

Amnestic mild cognitive impairment (aMCI) has been identified as a risk factor for dementia due to Alzheimer's disease. The medial temporal structures, which are crucial for memory processing, are the earliest affected regions in the brains of patients with aMCI, and episodic memory performance has been identified as a reliable way to discriminate between patients with aMCI and cognitively normal older adults. However, whether the detail and gist memory of patients with aMCI and cognitively normal older adults decay differently remains unclear. In this study, we hypothesized that detail and gist memory would be retrieved differentially, with a larger group performance gap in detail memory than in gist memory. In addition, we explored whether an increasing group performance gap between detail memory and gist memory groups would be observed over a 14-day period. Furthermore, we hypothesized that unisensory (audio-only) and multisensory (audiovisual) encoding would lead to differences in retrievals, with the multisensory condition reducing between and within-group performance gaps observed under the unisensory condition. The analyses conducted were analyses of covariance controlling for age, sex, and education and correlational analyses to examine behavioral performance and the association between behavioral data and brain variables. Compared with cognitively normal older adults, the patients with aMCI performed poorly on both detail and gist memory tests, and this performance gap persisted over time. Moreover, the memory performance of the patients with aMCI was enhanced by the provision of multisensory information, and bimodal input was significantly associated with medial temporal structure variables. Overall, our findings suggest that detail and gist memory decay differently, with a longer lasting group gap in gist memory than in detail memory. Multisensory encoding effectively reduced or overcame the between- and within-group gaps between time intervals, especially for gist memory, compared with unisensory encoding.

Age-related volumetric alterations in hippocampal subiculum region are associated with reduced retention of the "when" memory component.

Although age-related differences in episodic memory function are well established, the differential reduction in fine-grain memory components and its underlying hippocampal mechanism remains unclear. Hence, the current study investigated, first, age-related differences in the recollection of the four components (who, when, where, and what) of verbal episodic memory and, second, these components' associations with volumetric alterations in the hippocampal subfields. A total of 60 older and younger adults completed the Logical Memory test. The measurements of the volumes of the hippocampal subfields were obtained. The results revealed that older age was associated with poorer learning performance for when, where, and what components but not for who component; the reduced learning scores were differentially correlated with the age-related regional vulnerability of the dentate gyrus, CA1 subfield, and subiculum. The age-related vulnerability in the retention of the when component was associated with smaller subiculum, CA1, CA4, and dentate gyrus, but a reduction in the subiculum alone mediated the inverse relationship between age and the retention score for the when component. Our findings underscore the value of differentiating between memory components in evaluations of verbal contextual episodic memory which allows the analyst to examine aging-related associations between subtle cognitive changes and hippocampal substructures.

Apolipoprotein E ε4 Allele Is Associated with Reduced Retention of the "Where" Memory Component in Cognitively Intact Older Adults.

OBJECTIVE: The present study investigated the effect of the apolipoprotein E (ApoE) ε4 allele on the four memory components (i.e., who, when, where, and what) among cognitively intact older adults. METHODS: Participants comprised 47 cognitively intact older adults, who were classified into 2 groups based on the presence or absence of at least 1 ApoE ε4 allele. All participants completed standardized neuropsychological tests, including the Logical Memory subtest of the Wechsler Memory Scale-III with a revised scoring method. RESULTS: The results revealed that recollection for each component followed a pattern of who > what > when = where. Furthermore, a significant group-by-component-by-condition interaction indicated that the presence of the ApoE ε4 allele resulted in a disproportionately detrimental effect on the where component retention in the verbal episodic memory task; this finding was significantly correlated with hippocampal volumes. CONCLUSION: These results highlighted the importance of evaluating the subcomponents of verbal episodic memory to detect subtle cognitive differences related to ApoE ε4 status, which could help elucidate the mechanism behind the cascades caused by ApoE ε4 in the trajectories of cognitive aging.

Traditional Chinese version of the Mayer Salovey Caruso Emotional Intelligence Test (MSCEIT-TC): Its validation and application to schizophrenic individuals.

Schizophrenia is an illness that impairs a person's social cognition. The Mayer Salovey Caruso Emotional Intelligence Test (MSCEIT) is the most well-known test used to measure emotional intelligence (EI), which is a major component of social cognition. Given the absence of EI ability-based scales adapted to Chinese speakers, we translated the MSCEIT into a Traditional Chinese version (MSCEIT-TC) and validated this scale for use in schizophrenia studies. The specific aims were to validate the MSCEIT-TC, to develop a norm for the MSCEIT-TC, and use this norm to explore the EI performance of schizophrenic individuals. We included in our study seven hundred twenty-eight healthy controls and seventy-six individuals with schizophrenia. The results suggest that the MSCEIT-TC is reliable and valid when assessing EI. The results showed good discrimination and validity when comparing the two study groups. Impairment was the greatest for two branches Understanding and Managing Emotions, which implies that the deficits of schizophrenia individuals involve ToM (theory of mind) tasks. Deficits involving the negative scale of schizophrenia was related to impaired performance when the MSCEIT-TC was used (in branch 2, 3, 4, and the area Strategic). Our findings suggest that the MSCEIT-TC can be used for emotional studies in healthy Chinese and in clinical setting for investigating schizophrenic individuals.

Early Idiopathic Normal Pressure Hydrocephalus Patients With Neuropsychological Impairment Are Associated With Increased Fractional Anisotropy in the Anterior Thalamic Nucleus.

In this study, we aimed to investigate the reactive changes in diffusion tensor imaging (DTI)-derived diffusion metrics of the anterior thalamic nucleus (AN), a relaying center for the Papez circuit, in early idiopathic normal pressure hydrocephalus (iNPH) patients with memory impairment, as well as its correlation with the patients' neuropsychological performances. In total, 28 probable iNPH patients with symptom onset within 1 year and 17 control subjects were prospectively recruited between 2010 and 2013 for this institutional review board-approved study. Imaging studies including DTI and a neuropsychological assessment battery were performed in all subjects. Diffusion metrics were measured from the region of the AN using tract-deterministic seeding method by reconstructing the mammillo-thalamo-cingulate connections within the Papez circuit. Differences in diffusion metrics and memory assessment scores between the patient and control group were examined via the Mann-Whitney U test. Spearman correlation analyses were performed to examine associations between diffusion metrics of AN and neuropsychological tests within the patient group. We discovered that early iNPH patients exhibited marked elevations in fractional anisotropy, pure diffusion anisotropy, and axial diffusivity (all P < 0.01), as well as lower neuropsychological test scores including verbal and nonverbal memory (all P < 0.05) compared with normal control. Spearman rank correlation analyses did not disclose significant correlations between AN diffusion metrics and neuropsychological test scores in the patient group, whereas ranked scatter plots clearly demonstrated a dichotic sample distribution between patient and control samples. In summary, our study highlighted the potential compensatory role of the AN by increasing thalamocortical connectivity within the Papez circuit because memory function declines in early iNPH when early shunt treatment may potentially reverse the memory deficits.