RESUMO
OBJECTIVE: To investigate the effect of rapid rehabilitation nursing on the improvement of quality of life after super-miniPCNL (SMP) and the risk analysis of postoperative complications. METHODS: The clinical data of 124 SMP patients who were admitted from February 2019 to February 2021 were analyzed retrospectively. Thereinto, 58 cases received routine nursing were regarded as the control group (CG), and 66 received rapid rehabilitation nursing were considered as the observation group (OG). The negative emotions, pain relief, incidence of complications and quality of life were compared. In view of the occurrence of complications, patients were divided into complication group and non-complication group, and the risk factors were assessed by logistics regression. RESULTS: The time of fluid infusion, exhaust, defecation and hospitalization in the OG were shorter than those in the CG, and the difference was statistically remarkable (P<0.05). In the OG, the SF-36 and score of postoperative quality of life were obviously higher (P<0.05), while the postoperative visual analogue scale (VAS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were markedly lower. Logistics regression analysis manifested that the operation time, course of disease, stone residue, history of preoperative infection and nursing plan were independently correlated with complications. CONCLUSION: Rapid rehabilitation nursing for SMP patients is beneficial to accelerating postoperative recovery, reducing the occurrence of complications and improving quality of life.
RESUMO
OBJECTIVE: To study the liver targeted drug delivery system of TBMS--the effective anticancer component from Bolbstemma paniculatum, and to discuss the system's function of decreasing toxicity. METHOD: BCA was used as carrier material. The preparation through overall feedback dynamic techniques. The properties of preparation and toxicology were also technology of nanoparticles was optimized studied. Thenanoparticles' targeting in mice vivo was observed with transmission electron microscopy. The function of decreasing toxicity was researched by the XXTX-2000 automatic quantitative analysis management system. RESULT: D50 was 0.68 microm. Drug-loading rate and entrapment rate were 37.3% and 88.6% respectively. The release in vitro accorded with Weibull equation. The reaching release balance time and the t 1/2 extended 26 times and 19 times respectively comparing with injection. Nanoparticles mainly distributed in liver tissue. Their toxicity to lung and liver was evidently lower than injection. Nanoparticles' LD50 exceeded injection's by 13.5% and their stimulus was much lower than injection. CONCLUSION: The TBMS can be targeted to liver by liver targeted drug delivery system. At the same time, the problem about the toxicity hindering clinical application could be solved, which lays the foundation for the further studies on TBMS.
