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1.
Int J Biol Macromol ; 273(Pt 2): 133204, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38889831

RESUMO

Herein, the novel eco-friendly biopolymer electrolytes consisting of banana powder and konjac glucomannan host matrix doped with zinc acetate salt were successfully fabricated through simple casting technique. The biopolymer electrolyte exhibited satisfactory thermal stability and mechanical properties; tensile strength (13.82 MPa); elongation at break (60.52 %) and Young's modulus (93.2 MPa). The electrochemical studies were carried out in symmetrical cells Zn/Zn cells. Biopolymer electrolyte showed favorable ionic conductivity of 5.59 × 10-4 S/cm along with stable cycling performance. The potential stability was found to be 2.52 V. The as-prepared biopolymer electrolytes demonstrated the potential as green, simple yet effective biopolymer electrolytes for zinc-ion batteries.


Assuntos
Fontes de Energia Elétrica , Eletrólitos , Mananas , Musa , Pós , Zinco , Mananas/química , Musa/química , Eletrólitos/química , Zinco/química , Biopolímeros/química , Íons/química , Condutividade Elétrica , Resistência à Tração
2.
Mater Sci Eng C Mater Biol Appl ; 120: 111783, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33545910

RESUMO

Natural polymeric nanofibers-based materials for medical application is an intensive research area due to the unique features of natural polymeric nanofibers. Bacterial nanocellulose (BC) films containing various concentrations of mangosteen (Garcinia mangostana) peel extract were prepared and evaluated as a multifunctional nanofiber film. The extract was absorbed into BC hydrogel and air dried to entrap the extract into nanofiber network. The resulting films contained about 3, 35, and 294 mg of total phenolic compounds and 2, 24, and 250 mg of α-mangostin per cm3 of the dried films. The film containing the highest phenolic compounds and α-mangostin performed the inhibitory effect to Staphylococcus epidermidis, Propionibacterium acnes, and Staphylococcus aureus. High anticancer activity against B16F10 melanoma and MCF-7 breast cancer cells having viabilities of 10 and 5%, respectively after 48 h were detected after the treatments with the film. However, the film had a low toxicity against normal fibroblast and keratinocyte cells with 41 and 99% viability, respectively. The research suggested that the prepared films were a multifunctional nanofiber films with antimicrobial and anticancer properties.


Assuntos
Anti-Infecciosos , Garcinia mangostana , Nanofibras , Xantonas , Antibacterianos/farmacologia , Anti-Infecciosos/farmacologia , Humanos , Extratos Vegetais/farmacologia , Xantonas/farmacologia
3.
Molecules ; 25(17)2020 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-32825570

RESUMO

Multifunctional biopolymer composites comprising mechanically-disintegrated bacterial cellulose, alginate, gelatin and curcumin plasticized with glycerol were successfully fabricated through a simple, facile, cost-effective mechanical blending and casting method. SEM images indicate a well-distributed structure of the composites. The water contact angles existed in the range of 50-70°. Measured water vapor permeability values were 300-800 g/m2/24 h, which were comparable with those of commercial dressing products. No release of curcumin from the films was observed during the immersion in PBS and artificial saliva, and the fluid uptakes were in the range of 100-700%. Films were stretchable and provided appropriate stiffness and enduring deformation. Hydrated films adhered firmly onto the skin. In vitro mucoadhesion time was found in the range of 0.5-6 h with porcine mucosa as model membrane under artificial saliva medium. The curcumin-loaded films had substantial antibacterial activity against E. coli and S. aureus. The films showed non-cytotoxicity to human keratinocytes and human gingival fibroblasts but exhibited potent anticancer activity in oral cancer cells. Therefore, these curcumin-loaded films showed their potential for use as leave-on skin applications. These versatile films can be further developed to achieve desirable characteristics for local topical patches for wound care, periodontitis and oral cancer treatment.


Assuntos
Alginatos/química , Antibacterianos/farmacologia , Celulose/química , Curcumina/farmacologia , Gelatina/química , Neoplasias Bucais/tratamento farmacológico , Polímeros/química , Animais , Antineoplásicos/farmacologia , Bactérias/efeitos dos fármacos , Bactérias/crescimento & desenvolvimento , Bandagens , Células Cultivadas , Curcumina/química , Gengiva/citologia , Gengiva/efeitos dos fármacos , Glicerol/química , Humanos , Queratinócitos/citologia , Queratinócitos/efeitos dos fármacos , Suínos
4.
J Biomater Sci Polym Ed ; 30(11): 961-982, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31043124

RESUMO

Hydrogels from bacterial, algal, and animal cells-bacterial cellulose (BC), alginate, and gelatin, respectively-were combined to fabricate a biocomposite film (BCAGG) via an eco-friendly casting technique. In addition, glycerol was added as a plasticizer to improve the elasticity and water absorption capacity of the film. In this study, BC pellicles were simply deconstructed into fibrils suspension and then reconstructed into films with a supplement of alginate, gelatin and glycerol. The physical appearance of fabricated films resembled native BC but possessed improved ductility, enhanced flexibility, higher water uptake ability and better biocompatibility. The film was found to resist tearing under suture pullout strength in a hydrated state. In vitro cytotoxicity tests showed that the film was cytocompatible. A cell study using a human keratinocyte culture demonstrated enhanced cell adhesion, spreading, and proliferation on the BCAGG film compared with BC/alginate film. The BCAGG film therefore has significant potential for use in biomedical applications, particularly in dermal treatment, skin tissue regeneration, and wound healing.


Assuntos
Alginatos/química , Bactérias/química , Materiais Biocompatíveis/química , Celulose/química , Gelatina/química , Animais , Materiais Biocompatíveis/metabolismo , Adesão Celular , Linhagem Celular , Proliferação de Células , Fibroblastos/citologia , Glicerol/química , Glicerol/metabolismo , Humanos , Hidrogéis/química , Hidrogéis/metabolismo , Queratinócitos/citologia , Fenômenos Mecânicos , Membranas Artificiais , Camundongos , Oxigênio/química , Propriedades de Superfície , Engenharia Tecidual , Alicerces Teciduais/química , Água/química
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