Congenital acute lymphoblastic leukemia with chromosomal abnormalities including a translocation (1;4;22).

Cytogenetic studies in a patient with inborn ALL demonstrated identical and complex abnormalities in all the cells, indicating a monoclonal origin. These abnormalities included, among others, a translocation (1;4;22).

[Systemic reactive histiocytosis with hemophagocytosis and hemostasis disorders associated with septic granulomatosis]. / Histiocytose réactionnelle systémique avec hémophagocytose et troubles de l'hémostase associés à une granulomatose septique.

Authors describe a case of hemophagocytic systemic histiocytosis observed in a child suffering from chronic granulomatous disease, associated with septicemia due to Salmonella typhi murium; outcome was favorable. This type of histiocytic proliferation and activation usually induced by an infectious agent and combined with a congenital or acquired immunological disorder leads to severe clinical and hematological consequences which may contribute to a misleading diagnosis of malignant hematological disease. Moreover, systemic histiocytosis is constantly responsible for early blood clotting abnormalities concerning simultaneously coagulation and fibrinolysis; these changes have to be carefully examined before choosing either heparin or substitutive coagulant fractions.

[Cultures of bone marrow cells in semi-solid and liquid media; value in hemopathies (apropos of 4 cases)]. / Cultures de cellules médullaires en milieu semi-solide et en milieu liquide; intérêt dans les hémopathies (à propos de 4 observations).

Bone marrow cultures in semi-solid medium provide an estimate of progenitors in granulopoiesis and also in erythropoiesis. They are available data in leukemias and in bone marrow grafts. The cytogenetic studies of the abnormal clones show numeric and structural-abnormalities depending from the different types of leukemias and from the course of the disease.