Pancreatic insufficiency in HIV: is it possible?

Pancreatic involvement in AIDS is very important and common, but there are few studies in the literature concerning the pancreas in AIDS. Therefore, our research involves an important issue in the pancreatic field. The objective of the study was to evaluate the profile of HIV-infected patients with probable exocrine pancreatic insufficiency and its relation to the degree of human immunodeficiency virus (HIV) infection. This is a cross-sectional study carried out at Faculdade de Medicina do ABC in partnership with the basic health care unit Vila Guiomar in Santo André. We selected 118 individuals divided into four groups (a control group and three other groups composed of AIDS patients, separated according to CD4 levels); participants had an interview, completed a questionnaire, and had laboratory and imaging tests. The only clinical variables with significant differences among the studied groups were the use of highly active antiretroviral therapy (HAART), the incidence of opportunistic infections, the administration of chemoprophylaxis, and weight loss. There were no differences in the amylase, lipase, and steatocrit dosages among the groups. Levels of fecal elastase 1 were lower in the HIV patient groups (2, 3, and 4) when compared with the control group, although all of them showed average levels that were much higher than the cutoff point (200 µg/g). Only nonalcoholic individuals showed a relationship between diarrhea and alterations in elastase levels. A relationship between the use of HAART and exocrine pancreatic insufficiency in different phases of HIV infection could not be verified.

LESS sacrocolpopexy: step by step of a simplified knotless technique.

INTRODUCTION: Pelvic organ prolapse is an ordinary disease with around 200.000 surgeries performed annually in the US to treat this condition. The surgical treatment for complete vaginal vault prolapse after hysterectomy involves abdominal or vaginal sacrocolpopexy. The purpose of this video is to demonstrate the steps of a laparoendoscopic single-site surgery (LESS) sacrocolpopexy performed by a simplified knotless technique. MATERIALS AND METHODS: A 52 year-old female submitted a total hysterectomy five years ago due to miomatosis who developed vault prolapse and urinary incontinence after surgery. She was treated by transumbilical LESS cutaneous retractor and a surgical glove attached to three trocars through a 3.5 cm umbilical incision. Patient was positioned in lithotomy, the Y-shape polypropylene mesh was passed through the trocar. Only conventional laparoscopic instruments were used for intrabdominal dissection of vagina and peritoneum. The mesh was fixed to the vaginal fornix using 3 continuous sutures held in extremities by polymeric clips. The last helical suture was fixed by polymeric clips to the sacral periosteum from the promontory to achieve good vaginal positioning without tension. The posterior peritoneum was closed over the mesh. RESULTS: The operative time was 150 minutes, blood loss of approximately 100 mL and the patient was discharged after 18 hours with no immediate complications and a 3 months follow-up free of vault prolapse and urinary incontinence until now. CONCLUSIONS: LESS sacrocolpopexy performed with conventional instruments is feasible and a safe procedure reproducing surgical steps of conventional laparoscopic or robotic surgery.

Por que os pacientes são encaminhados ao urologista?: análise crítica dos encaminhamentos no município de São Bernardo do Campo / Why are patients referred to urological consultation?: critical analysis of referrals in São Bernardo do Campo

Introdução: A elevada demanda por atendimento urológico em São Bernardo do Campo gera uma espera para que pacientes sejam atendidos pelo urologista, após terem sido encaminhados pelo clínico. Objetivos: Avaliar condições associadas a encaminhamentos aos ambulatórios de Urologia da Faculdade de Medicina do ABC, no município. Métodos: Foram avaliados 106 relatórios de encaminhamento de pacientes para consulta urológica em São Bernardo do Campo, entre dezembro de 2009 e março de 2010, e sua correlação com os dados obtidos em consulta urológica. Resultados: Os principais motivos para encaminhamento urológico foram o exame da próstata (29,2%) e a urolitíase (22,6%). Houve concordância entre o motivo referido e o diagnóstico após consulta urológica em 55,7% dos casos, discordância em 20,8% e ausência de menção do motivo da consulta em 23,6%. Observouse que 56,6% dos pacientes não levaram os exames mínimos necessários à consulta com o especialista. Dos encaminhamentos por disfunções sexuais, 17% referiam o real motivo para consulta. Houve concordância em 100% dos encaminhamentos de pacientes oncológicos. Médicos formados há mais de 30 anos encaminharam pacientes mais precisamente. Conclusão: A imprecisão no encaminhamento aos ambulatórios de Urologia e a inexistência de protocolos para tal contribuem para a morosidade do sistema. Propõe-se o uso de protocolos para solicitar exames, previamente ao encaminhamento ao urologista, e o reforço quanto à importância da precisão do encaminhamento junto aos médicos responsáveis pela atenção primária.

Introduction: High demand to urological care in São Bernardo do Campo leads to a delay from the primary care physician referral until urologist?sconsultation. Objetives: To evaluate conditions associated with referrals to the Urology outpatient clinic from Faculdade de Medicina do ABC in thismunicipality. Methods: We analyzed 106 urological referral reports of patients in São Bernardo do Campo, from December 2009 to March 2010, and compared to data obtained after urologic consultation. Results: The main reasons for urological referral were prostatic check-up (29.2%) and urolithiasis (22.6%). There was similarity between referral report and diagnoses after urological consultation in 55.7% of the cases, discordance in 20.8%, while no reason was informed in 23.6% of referral reports; 56.6% of the pacients did not bring their exams to specialist?s consultation. Referrals for sexual disfunction held the real reason for consultation in 17% of the cases, while concordance was found in every referral for oncologyc disease. Moreover, doctors graduated for more than 30 years usually referred pacients more precisely. Conclusion: The lack of accuracy in patient's referral to urological clinics and the absence of referral protocols contribute to the delay in the health care system. We recommend the adoption of guidelines to aid requesting subsidiary exams before referring patients to the urologist as well as the reinforcement towards the need of a proper referral by primary care physicians.

Biophysiologic considerations in cryoablation: a practical mechanistic molecular review.

Cryotherapy techniques date back as far as the mid-1800s, when James Arnott demonstrated the effectiveness of salt/ice mixtures in palliation of breast, uterine, and skin cancers. Subsequent advances saw the use of liquid air and solid carbon dioxide in the treatment of various conditions, particularly benign dermatologic lesions (1). Cooper and Lee introduced the first automated cryosurgical apparatus cooled by circulating liquid nitrogen in 1961 and initially used it for treating neuromuscular disorders (2). Liquid nitrogen probes were soon being used in the treatment of benign prostatic hypertrophy and prostate cancer, though complications were quite common, resulting in the procedures falling out of favor until the 1990s, when intraoperative ultrasound techniques were developed, allowing more accurate monitoring of the freezing process (1). The advent of "third-generation" argon and helium gas probes in 2000 and preoperative computer thermal mapping techniques have allowed even more precise placement, temperature control, and further reduction in post-procedural morbidity (3). Cryosurgical techniques are currently used to treat a wide variety of conditions, but significant urologic indications include treatment of low and intermediate risk prostate cancer and renal cell carcinoma < 4 cm in diameter.

Validation of fecal elastase-1 determination using immunoenzymatic assay in HIV-infected patients.

Pancreatic elastase-1 is a proteolytic enzyme exclusively produced in the pancreas, is stable when passing through the bowel, and its determination is associated with chronic pancreatitis. The clinical diagnosis of pancreatitis is based on anamnesis, physical examination, radiological, sonographic, endoscopic, and laboratory findings. Nowadays, there is a test for the determination of fecal elastase-1, by enzymatic reaction (enzyme-linked immunosorbent assay, ELISA), which specifically determines human elastase-1, promoting the pancreatic function evaluation. Parameters such as linearity, calibration curve, sensitivity, specificity, precision, accuracy, recovery, and receiver operator characteristic (ROC) curve are used to evaluate the test. The aim of this study was the validation of the immunoenzymatic assay (ELISA) and the use of its results in patients with HIV, alcoholics, and under antiretroviral therapy. The study involved 157 patients, 95 of them were HIV-infected, and 62 were completely healthy. The elastase-1 ELISA kit from Bioserv was used, and we noted that the obtained results were linear, sensitive, precise, and accurate. Moreover, our results suggest that this test can be a laboratory evaluation to determine the relationship of pancreatitis with alcohol use, but not its association with antiretroviral use in HIV patients (P=0.424). This test is useful to diagnose pathologies related to pancreatic insufficiency.

Prevalence of the burnout syndrome among Brazilian medical oncologists.

INTRODUCTION: Burnout syndrome which is prevalent among oncologists is characterized by three aspects: emotional exhaustion, depersonalization and low personal accomplishment. The purpose was to evaluate prevalence of the burnout syndrome among Brazilian medical oncologists and the variables that correlate with its presence. METHODS: A survey was conducted with members of the Brazilian Society of Medical Oncology (SBOC) who received three questionnaires (general, Maslach burnout questionnaire and an opinion survey) mailed to all 458 members. RESULTS: Response rate was of 22.3%. According to the criteria proposed by Grunfeld, which consider burnout present when at least one of the aspects is severely abnormal, prevalence of this syndrome was 68.6% (95% confidence interval, CI: 58.68% to 77.45%). By multivariate analysis having a hobby/physical activity, a religious affiliation, older age, living with a companion and rating vacation time as sufficient were correlated significantly and independently with burnout syndrome. CONCLUSIONS: The burnout syndrome is prevalent among Brazilian oncologists. Oncologists having sufficient personal and social resources to engage in a hobby, physical activity, have enough vacation time and religious activities are at lower risk of developing burnout.

Prevalence of the burnout syndrome among Brazilian medical oncologists

INTRODUCTION: Burnout syndrome which is prevalent among oncologists is characterized by three aspects: emotional exhaustion, depersonalization and low personal accomplishment. The purpose was to evaluate prevalence of the burnout syndrome among Brazilian medical oncologists and the variables that correlate with its presence. METHODS: A survey was conducted with members of the Brazilian Society of Medical Oncology (SBOC) who received three questionnaires (general, Maslach burnout questionnaire and an opinion survey) mailed to all 458 members. RESULTS: Response rate was of 22.3 percent. According to the criteria proposed by Grunfeld, which consider burnout present when at least one of the aspects is severely abnormal, prevalence of this syndrome was 68.6 percent (95 percent confidence interval, CI: 58.68 percent to 77.45 percent). By multivariate analysis having a hobby/physical activity, a religious affiliation, older age, living with a companion and rating vacation time as sufficient were correlated significantly and independently with burnout syndrome. CONCLUSIONS: The burnout syndrome is prevalent among Brazilian oncologists. Oncologists having sufficient personal and social resources to engage in a hobby, physical activity, have enough vacation time and religious activities are at lower risk of developing burnout.

INTRODUÇÃO: A Síndrome da Estafa Profissional (SEP) é considerada uma doença caracterizada por três componentes básicos: exaustão emocional (EE), despersonalização (DP) e reduzida realização pessoal (RP), sendo identificada em oncologistas. OBJETIVO: Analisar a prevalência da SEP entre oncologistas clínicos e possíveis fatores relacionados. MÉTODOS: Foram enviados três questionários (Questionário Geral, Questionário Maslach de Burnout e Questionário de Opinião) para 458 cancerologistas cadastrados na Sociedade Brasileira de Oncologia Clínica (SBOC). RESULTADOS: A taxa de resposta foi de 20 por cento. 43,3 por cento dos entrevistados demonstraram nível baixo de EE, 57,8 por cento apresentaram nível alto de DP e 55,5 por cento alta RP. Para avaliarmos a presença da SEP, utilizamos o critério de Ramirez, que considera as três dimensões em nível grave (8,9 por cento) e o de Grunfeld que considera pelo menos um dos três domínios em nível grave (68,9 por cento). Pelos critérios de Ramirez, houve correlação negativa com praticar exercícios/hobby (p=0,0007) e crer em uma religião (p=0,0445) com SEP. Já por Grunfeld, se correlacionou positivamente com morar com o companheiro (p=0,0054) e considerar o tempo de férias insuficiente (p=0,0037). Por ambos os critérios, foi constatada uma correlação positiva entre ter a síndrome e não optar por oncologia novamente se tivesse essa oportunidade. CONCLUSÃO: A SEP é muito prevalente entre os oncologistas clínicos. Porém, a maioria destes profissionais optaria novamente por essa especialidade. Prática de exercícios/hobby, tempo de férias suficiente e crer em uma religião surgiram como possíveis fatores para prevenir esta síndrome.