RESUMO
The hepatoprotective properties of altan (obtained on the basis of ellagotannines from the cones of black alder Alnus glutinosa) are studied on the model of acute damage to the liver with tetrachloromethane. It is found that altan exhibits the hepatoprotective activity even in a dose of 1 mg/kg which is tenfold smaller compared to the dose of traditional flavonoid-based drugs. Altan limits choleopoiesis disorder, has an antiinflammatory and membrane stabilizing effect, and recovers physiological antioxidant system.
Assuntos
Fígado/efeitos dos fármacos , Taninos/uso terapêutico , Árvores , Doença Aguda , Animais , Intoxicação por Tetracloreto de Carbono/complicações , Intoxicação por Tetracloreto de Carbono/tratamento farmacológico , Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Avaliação Pré-Clínica de Medicamentos , Flavonoides/uso terapêutico , Extratos Vegetais/uso terapêutico , Ratos , ComprimidosRESUMO
The hepatoprotective properties of the flavonoid preparation piflamine of field-peas grass were studied on a model of experimental paracetamol liver damage. Piflamine was found to normalize the parameters of carbohydrate, protein, and lipid metabolism, increase the activity of the antioxidant system, and restore the processes of bile production and bile secretion. The drug is prospective due to its quite cheap and available source of raw materials.
