1.
J Med Chem
; 53(5): 2314-8, 2010 Mar 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20158203
RESUMO
The screening of a small focused library of rhodanine derivatives as inhibitors of Bcl-2 proteins led to the discovery of two structurally related compounds with different binding profiles against the Bcl-XL and the Mcl-1 proteins. Subsequent NMR studies with mutant proteins and in silico docking studies provide a possible rationale for the observed specificity.