Preattentive discrimination of across-category and within-category change in consonant-vowel syllable.

Event-related potentials to infrequently presented spoken deviant syllables /pi/ and /po/ among repetitive standard [see text] syllables were recorded in Thai study participants who ignored these stimuli while reading books of their choices. The vowel across-category and within-category changes elicited a change-specific mismatch negativity response. The across-category and within-category change discrimination of vowels in consonant-vowel syllable was also assessed using the low-resolution electromagnetic tomography. The results of low-resolution electromagnetic tomography mismatch negativity generator analysis suggest that the within-category change perception of vowels is analyzed as the change in physical features of the stimuli, thus predominantly activating the right temporal cortex. In contrast, the left temporal cortex is predominantly activated in the across-category change perception of vowels, emphasizing the role of the left hemisphere in speech processing already at a preattentive processing level also in consonant-vowel syllables. The results support the hypothesis that a part of the superior temporal gyrus contains neurons specialized for speech perception.

Preattentive processing of lexical tone perception by the human brain as indexed by the mismatch negativity paradigm.

Mismatch negativity (MMN) was used to investigate the processing of the discrimination between native and non-native CV syllables in tonal languages. MMN elicited by the native word was greater than that elicited by the non-native word. Hearing a native-language deviant significantly altered the elicited MMN in both amplitude and scalp voltage field distribution, reflecting the presence of a long-term memory trace for spoken words in tonal languages.

Platelet serotonin transporter in schizophrenic patients with and without neuroleptic treatment.

Among various hypotheses put forth to account for the etiology of schizophrenia, the abnormal function of serotonergic system has recently gained marked interest. Our previous study showed that drug-free schizophrenic patients had a significant increase in maximum numbers (B(max)) of platelet 5-HT(2A) receptors that declined to normal level after treatment with different neuroleptic drugs. To elucidate the role of the serotonin system in schizophrenia, the serotonin transporters on human platelets were examined in this study. Platelet serotonin transporters obtained from normal control subjects and schizophrenic patients were identified by using [(3)H]imipramine as the radioligand and fluoxetine to define the non-specific binding. The data showed that the mean B(max) of serotonin transporter sites for schizophrenic patients without neuroleptic therapy was significantly higher than in normal controls. The B(max) values for schizophrenic patients on phenothiazine, butyrophenone, thioxanthene and serotonin-dopamine antagonist (SDA) therapies were significantly lower than the B(max) values obtained from schizophrenic patients without neuroleptic therapy, and were comparable to those found in normal control subjects. The dissociation equilibrium constant (K(d)) values in all subject groups remained unchanged. The effect of various medication periods on platelet serotonin transporters was also studied. We found that, B(max) values of 1-4 weeks, 1-4 months, 4-12 months and >1 year of neuroleptic therapies were significantly decreased when compared with the unmedicated group. Significant reduction of brief psychiatric rating scale (BPRS) occurred in all types of neuroleptics and every period of drug treatments compared with the unmedicated group. The present results indicate that alteration of platelet serotonin transporters is associated with schizophrenia. Treatment with various types of neuroleptics suppresses the hypersensitivity of platelet serotonin transporters. The mechanisms of how neuroleptics achieve their therapeutic effects, whether they act via or modulate serotonin system in certain brain area, still need to be further evaluated.