1.
Bioorg Med Chem Lett
; 24(4): 1144-7, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24461291
RESUMO
A design for the selective release of drug molecules in the liver was tested, involving the attachment of a representative active agent by an ester linkage to various 2-substituted 5-aminovaleric acid carbamates. The anticipated pathway of carboxylesterase-1-mediated carbamate cleavage followed by lactamization and drug release was frustrated by unexpectedly high sensitivity of the ester linkage toward hydrolysis by carboxylesterase-2 and other microsomal components.