Effect of polyunsaturated phosphatidyl-choline on lipid transport system in alcoholic liver injury.

The aim of this study was to determine whether serum lipid composition and lipolytic activities in alcoholinduced liver dystrophy were modified by the co-administration of polyunsaturated phosphatidylcholine (PPC). Chronic alcohol intoxication was induced in rats by intragastric ethanol administration of 3.5 g/kg body weight per day over 56 days. Aqueous PPC suspension was given intragastrally in doses of 100 and 300 mg/kg body weight. Chronic alcohol intoxication led to the development of protein and lipid dystrophy of hepatocytes. PPC partially prevented alcoholic injury of the liver cells and had a normalizing effect on cholesterol esterification, lipolysis of lipoproteins and on the fatty acid composition of the main lipoprotein classes.

[The effect of factors stimulating proliferation of hepatocytes on cholesterol esterification in the serum during liver regeneration]. / Deistvie faktorov, stimuliruiushchikh proliferatsiiu gepatotsitov, na protsess ésterifikatsii kholesterina v syvorotke krovi pri regeneratsii pecheni.

Two-step regeneration of rat liver tissue was observed after partial hepatectomy. The first step involved mitosis of hepatocytes and the second step--division of the cells containing two nuclei and hypertrophy of hepatocytes. Both these steps of liver tissue regeneration were accompanied by hypercholesterolemia and a decrease in the cholesterol esterification activity in blood serum. The factors, stimulating hepatocyte proliferation, accelerated the reparative liver tissue regeneration due to activation of mitosis and the early division of the cells containing two nuclei. At the same time, the highest regeneration of the cholesterol esterification system was detected in circulation.