1.
Bioorg Med Chem Lett
; 25(23): 5566-9, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26508550
RESUMO
Derivatives of phaeosphaeride A (PPA) were synthesised and characterised; then anti-cancer studies were carried out on the A549 cancer cell line. It was found that the acetyl derivative (compound 3) displayed comparable in vitro cytotoxicity to that of PPA (EC50=49±7 µM and EC50=46±5 µM, respectively), while chloroacetyl derivative 6 (EC50=33±7 µM) was found to have better efficacy towards the A549 cancer cell line.