RESUMO
HIV Associated Dementia (HAD) is a complication of HIV infection in developed countries and is still poorly defined in resource-limited settings. In this study we investigated the expression of the monocyte phenotype CD14CD16HLADR and the inflammatory profiles in monocytes supernatants by surface-enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry in a cohort of HAD and non-HAD Thai volunteers prior to the initiation of ARV. The CD14CD16HLADR phenotype was significantly increased in monocytes from HAD and non-HAD versus negative controls, but there was no difference in phenotype and in the secretion protein profiles between the two seropositive groups. In addition, monocytes supernatants from HAD and non-HAD did not induced apoptosis or cell death in brain aggregate culture. In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts.
Assuntos
Complexo AIDS Demência/patologia , Antígenos CD4/metabolismo , Infecções por HIV/patologia , HIV-1 , Monócitos/metabolismo , Complexo AIDS Demência/metabolismo , Adulto , Contagem de Linfócito CD4 , Linfócitos T CD4-Positivos/patologia , Estudos de Coortes , Ensaio de Imunoadsorção Enzimática/métodos , Feminino , Infecções por HIV/metabolismo , Humanos , Técnicas In Vitro , Masculino , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz , Estatísticas não Paramétricas , Tailândia/epidemiologia , Carga ViralRESUMO
An international telehealth symposium was conducted between healthcare institutions in Hawaii and Thailand using a combination of Asynchronous Transfer Mode, and Internet2 connectivity. Military and civilian experts exchanged information on the acute and rehabilitative care of landmine victims in Southeast Asia. Videoconferencing can promote civil-military cooperation in healthcare fields that have multiple international stakeholders.
Assuntos
Traumatismos por Explosões/terapia , Internacionalidade , Internet , Telemedicina , Comunicação por Videoconferência , Traumatismos por Explosões/reabilitação , Havaí , Hospitais Militares , Hospitais Pediátricos , Humanos , TailândiaRESUMO
International medical education sessions have been successfully conducted by videoconferencing using Internet2. The sessions were between two tertiary care medical centres, in Honolulu and Bangkok. However, video quality was lower than for similar sessions using ISDN and audience satisfaction was less. The main reasons for the lower quality were network congestion and bandwidth allocation by the videoconferencing equipment. Software to ensure quality of service is available, but is not easy to implement. There were also network security problems and the costs were high. Our international videoconferences averaged 40-50 hours per year, an activity level at which connection costs were lower for ISDN than for Internet2. It appears that Internet2 videoconferencing for medical education is best reserved for academic institutions that have other high-bandwidth network requirements.
