Assessment of Language Function in Older Mandarin-Speaking Adults with Mild Cognitive Impairment using Multifaceted Language Tests.

BACKGROUND: Individuals with amnestic mild cognitive impairment (aMCI), especially for those with multidomain cognitive deficits, should be clinically examined for determining risk of developing Alzheimer's disease. English-speakers with aMCI exhibit language impairments mostly at the lexical-semantic level. Given that the language processing of Mandarin Chinese is different from that of alphabetic languages, whether previous findings for English-speakers with aMCI can be generalized to Mandarin Chinese speakers with aMCI remains unclear. OBJECTIVE: This study examined the multifaceted language functions of Mandarin Chinese speakers with aMCI and compared them with those without cognitive impairment by using a newly developed language test battery. METHODS: Twenty-three individuals with aMCI and 29 individuals without cognitive impairment were recruited. The new language test battery comprises five language domains (oral production, auditory and reading comprehension, reading aloud, repetition, and writing). RESULTS: Compared with the controls, the individuals with aMCI exhibited poorer performance in the oral production and auditory and reading comprehension domains, especially on tests involving effortful lexical and semantic processing. Moreover, the aMCI group made more semantic naming errors compared with their counterparts and tended to experience difficulty in processing items belonging to the categories of living objects. CONCLUSIONS: The pattern identified in the present study is similar to that of English-speaking individuals with aMCI across multiple language domains. Incorporating language tests involving lexical and semantic processing into clinical practice is essential and can help identify early language dysfunction in Mandarin Chinese speakers with aMCI.

Apolipoprotein E ε4 Allele Is Associated with Reduced Retention of the "Where" Memory Component in Cognitively Intact Older Adults.

OBJECTIVE: The present study investigated the effect of the apolipoprotein E (ApoE) ε4 allele on the four memory components (i.e., who, when, where, and what) among cognitively intact older adults. METHODS: Participants comprised 47 cognitively intact older adults, who were classified into 2 groups based on the presence or absence of at least 1 ApoE ε4 allele. All participants completed standardized neuropsychological tests, including the Logical Memory subtest of the Wechsler Memory Scale-III with a revised scoring method. RESULTS: The results revealed that recollection for each component followed a pattern of who > what > when = where. Furthermore, a significant group-by-component-by-condition interaction indicated that the presence of the ApoE ε4 allele resulted in a disproportionately detrimental effect on the where component retention in the verbal episodic memory task; this finding was significantly correlated with hippocampal volumes. CONCLUSION: These results highlighted the importance of evaluating the subcomponents of verbal episodic memory to detect subtle cognitive differences related to ApoE ε4 status, which could help elucidate the mechanism behind the cascades caused by ApoE ε4 in the trajectories of cognitive aging.