Energy transition or energy diversification? Assessing the complexity of energy ecosystem towards transiting a climate neutral society.

The recent shift in the global energy paradigm and the expansion of renewable energy, spurred by the global COVID-19 epidemic and as a consequence of the Russian-Ukrainian conflict, require assessing the complexity of the energy ecosystem to transition to a low-carbon economy. While the most of the literature is centered on analyzing the energy sector and the transformation determined by the energy transition to renewables or investigating the need for energy diversification, there has been less attention focused to assessing the complexity of energy ecosystems toward transiting a climate neutral society, despite determinant potential of policy implications. The main aim of this study is to analyze the complexity behavior and the resilience of the Romanian energy system in the period 2015 to 2020 and to compare the complexity situations in 2015, 2016 and 2020. The study is based on the quantitative complexity management approach developed by Ontonix™ (2022) and it is carried out using the OntoSpace™ software. The results indicate higher complexity of the Romanian energy ecosystem since 2016, which highlights a higher difficulty of governing it.

Risk Factors for Medication-Related Osteonecrosis of the Jaw-A Binomial Analysis of Data of Cancer Patients from Craiova and Constanta Treated with Zoledronic Acid.

MRONJ (Medication-Related Osteonecrosis of the Jaw) is a condition observed in a subset of cancer patients who have undergone treatment with zoledronic acid in order to either prevent or treat bone metastases. The primary aim of this research was to establish the importance of risk factors in the development of medication-related osteonecrosis of the jaw in cancer patients receiving zoledronic acid therapy for bone metastases. The present study is an observational retrospective investigation conducted at two university centers, namely, Craiova and Constanța, and included cancer patients treated with zoledronic acid. The medical records of the patients were obtained over a four-year timeframe spanning from June 2018 to June 2022. The data analysis was carried out between January 2021 and October 2022. Patients were treated for cancer, bone metastases, and MRONJ according to the international guidelines. The research investigated a cohort of 174 cancer patients (109 females and 65 males) aged between 22 and 84 years (with a mean age 64.65 ± 10.72 years) seeking treatment at oncology clinics situated in Craiova and Constanța. The study conducted a binomial logistic regression to analyze ten predictor variables, namely, gender, age, smoking status, treatment duration, chemotherapy, radiotherapy, endocrine therapy, presence of diabetes mellitus (DM), obesity, and hypertension (HT). The results of the analysis revealed that only five of the ten predictor variables were statistically significant for MRONJ occurrence: duration of treatment (p < 0.005), chemotherapy (p = 0.007), and hypertension (p = 0.002) as risk factors, and endocrine therapy (p = 0.001) and obesity (p = 0.024) as protective factors.