[Cyclic nucleotides in patients with cancer and non-tumoral diseases of the gastrointestinal tract]. / Tsiklicheskie nukleotidy u bol'nykh rakom i neopukholevymi zabolevaniiami zheludochno-kishechnogo trakta.

The intracellular levels of adenosine-3,5-monophosphate and guanosine-3,5-monophosphate were compared in 76 patients with different patterns of stomach pathology and 98 cases of colonic diseases. A significant decrease in concentration of cyclic nucleotides in malignant tumors of the digestive tract was observed. The results point to essential functional changes taking place at cellular level in the grossly intact mucosa of the stomach and colon in tumor pathology.

[Labeling index in colonic cancer, polyps and polyposis and nonspecific colitis]. / Indeks metki pri rake, polipakh, polipoze tolstoi kishki i nespetsificheskikh kolitakh.

Thymidine historadiography was employed to study labelling index in tumors and grossly-unaltered mucosa of large bowel in 34 cases of colorectal cancer and 67 patients with single polyps, polyposis and villous tumors of large bowel and suffering from nonspecific colitis. Mean labelling index in tumor tissue was established at 5.49, in normal mucosa of large bowel of healthy subjects--1.19, and in colitis, polyps and villous tumors--2.32, 4.24 and 5.84%, respectively. Labelling index increased with the degree of pathologic changes in mucosal epithelium of large bowel. Thymidine historadiography should be used in formation of groups at risk for large bowel cancer.