RESUMO
Activity of adenosine deaminase (EC 3.5.4.4) was studied in thrombocytes of donors and patients with various hematological diseases. The enzymatic activity was decreased in acute leukemia, chronic myeloleukemia, chronic leukemia and blast transformation myeloma, microspherocytic and hypoplastic anemias. Variable level of the activity was observed in chronic lympholeukemia and non-Hodgkin disease. In all the diseases studied functions of thrombocytes were altered after treatment with various aggregating agents (ADP, thrombin, collagen, adrenaline, ristomycin).
Assuntos
Adenosina Desaminase/sangue , Plaquetas/enzimologia , Doenças Hematológicas/enzimologia , Nucleosídeo Desaminases/sangue , Anemia/sangue , Anemia/enzimologia , Doenças Hematológicas/sangue , Humanos , Transtornos Linfoproliferativos/sangue , Transtornos Linfoproliferativos/enzimologia , Transtornos Mieloproliferativos/sangue , Transtornos Mieloproliferativos/enzimologia , Agregação PlaquetáriaAssuntos
Transtornos Plaquetários/genética , Plaquetas/fisiologia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , SíndromeAssuntos
Coagulação Intravascular Disseminada/etiologia , Leucemia Linfoide/complicações , Leucemia Mieloide Aguda/complicações , Testes de Coagulação Sanguínea , Coagulação Intravascular Disseminada/fisiopatologia , Humanos , Leucemia Linfoide/fisiopatologia , Leucemia Mieloide/complicações , Leucemia Mieloide/fisiopatologia , Leucemia Mieloide Aguda/fisiopatologiaAssuntos
Anemia Aplástica/patologia , Vasos Sanguíneos/patologia , Adolescente , Adulto , Anemia Aplástica/sangue , Feminino , Glicoproteínas/sangue , Humanos , Hialuronoglucosaminidase/antagonistas & inibidores , Hialuronoglucosaminidase/sangue , Masculino , Pessoa de Meia-Idade , Orosomucoide/análise , Ácidos Siálicos/sangue , Baço/patologiaRESUMO
The authors sum up the data on the hemostatic action of dicinon in 20 patients with hypoplastic anemia. Dicinon proved to promote the arrest of a hemorrhagic syndrome in cases in which the changes in the vascular factors prevailed in the pathogenesis of the hemorrhagic tendency.