Equine ulcerative keratomycosis: visual outcome and ocular survival in 39 cases (1987-1996).

The medical records of 39 horses treated for ulcerative keratomycosis over a 10 year period were reviewed. Records were evaluated to determine the medical and/or surgical treatment protocol, visual outcome, globe survival and whether the outcome was influenced by the fungal species isolated. Stromal abscesses and iris prolapses caused by fungi were not included. Twenty of the horses underwent medical treatment only, and 19 horses had combined medical and surgical treatment. Most horses had been treated with topical antibiotics (n = 32) and atropine sulphate (n = 23) prior to referral; topical antifungals had been employed less frequently (n = 14). Fungi were identified by cytology (n = 31), culture (n = 33) and/or surgical histopathology (n = 6). Aspergillus (n = 13) and Fusarium (n = 10) were the most commonly isolated fungi. Miconazole (n = 35) was the most common topical antifungal medication utilised. Median duration of treatment was 48 days (range 31-192 days). Associated bacterial infection (n = 13) was frequently encountered. Visual outcome was favourable in 36/39 (92.3%) eyes. All eyes (20/20) retained vision following medical management only, and 16/19 (84%) retained vision following combined medical and surgical therapy. All medically treated horses (20/20), and 17/19 (89%) of those treated medically and surgically retained their globes. Overall ocular survival was favourable in 37/39 (94.9 %) eyes. Aggressive therapy can result in successful results for equine ulcerative keratomycosis.

Ophthalmic disease as the presenting complaint in five dogs with multiple myeloma.

Five dogs with multiple myeloma were seen initially because of vision loss or abnormal-appearing eyes. Each case had at least one ophthalmic abnormality (i.e., glaucoma, retinal detachment, anterior uveitis, or intraretinal hemorrhages). In each of four cases, the multiple myeloma went into remission with chemotherapy. Cases with retinal detachments without anterior uveitis or with anterior uveitis that was controlled with medication regained vision even when the retinas had been detached for several months.

Visual outcome and ocular survival following iris prolapse in the horse: a review of 32 cases.

The medical records of 32 horses treated for iris prolapse (IP) during an 8 year period, at the University of Florida Veterinary Medical Teaching Hospital, were reviewed. Iris prolapse was associated with perforated corneal ulcers in 15 horses (47%), ruptured stromal abscesses in 2 horses (6%), and full thickness corneal lacerations in 15 horses (47%). Initial ophthalmic examinations revealed IP with severe iridocyclitis in all eyes and keratomalacia in 8 eyes with corneal ulcers, one with a stromal abscess and 1 with a corneal laceration. Hyphema was present in 7 eyes with corneal lacerations. Thirty horses were managed with combined medical and surgical therapy. Two horses were only treated medically with topically administered antibiotics. Of the 24 perforations surgically repaired, 21 were closed primarily and 13 were then covered with a conjunctival graft. After combined therapy and a minimum of 4 months of follow-up, vision was retained in 6 of the horses (40%) with perforating corneal disease and 5 of the horses (33%) with perforating corneal lacerations. Post operatively, of the 11 (37%) horses blind at discharge, 6 (55%) subsequently developed phthisis bulbi. Enucleations were performed in 4 cases with extensive keratomalacia and/or endophthalmitis, 2 cases with limbal rupture and total hyphema, and one case with a chronic IP. One horse was subjected to euthanasia after 3 surgical treatments failed to stabilise stromal melting. Horses presented with ulcerative keratitis of fewer than 15 days duration, or horses with corneal lacerations less than 15 mm in length, tended to have a favourable visual outcome. Keratomalacia, hyphema, corneal lacerations longer than 15 mm and lacerations extending to, along, or beyond the limbus, adversely influenced visual outcome. Iridectomy did not appear clinically to exacerbate anterior uveitis or adversely affect visual outcome. Ocular survival following combined therapy was 80% (12/15) in horses with corneal lacerations and 67% (10/15) in horses with ulcerative keratitis.

Cataracts and crooked toes in Brahma chickens.

In 1991, 69% of the cockerels and 15% of the pullets in an inbred flock of approximately 200 dark and light Brahma chickens had unilateral or bilateral cataracts and crooked toes. Affected chickens were normal at hatching but developed cataracts with or without crooked toes by 6 months of age. The cataracts were initially focal and polar but progressed to be diffuse throughout the lenticular cortex. The crooked toes involved one or more of the second, third, and fourth digits and were due to a medial deviation of the distal aspect of the first phalanx. The cataracts and crooked toes were considered likely due to a hereditary defect, based on the following: the history of flock inbreeding; the lack of historical, clinical, or pathological evidence of avian encephalomyelitis or Marek's disease; the presence of lesions only in Brahma chickens and not in the approximately 200 other chickens on the farm kept under the same management and environmental conditions; the age at which the lesions occurred; and the nature of the lesions.